Nevirapine-d4
- Product Name
- Nevirapine-d4
- CAS No.
- 1051418-95-1
- Chemical Name
- Nevirapine-d4
- Synonyms
- Nevirapine-d4;B2Nevirapine-d4;HIV-1 inhibitor-58;Nevirapine methyl D4;Nevirapine-d4 (cyclopropyl-2,2,3,3-d4);d4-11-cyclopropyl-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one;11-cyclopropyl-2,2,3,3-d4-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
- CBNumber
- CB02675121
- Molecular Formula
- C15H14N4O
- Formula Weight
- 266.3
- MOL File
- 1051418-95-1.mol
Nevirapine-d4 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 2.5 mg/ml
- form
- A solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 28093
- Product name
- Nevirapine-d4
- Packaging
- 1mg
- Price
- $303
- Updated
- 2024/03/01
- Product number
- 28093
- Product name
- Nevirapine-d4
- Packaging
- 5mg
- Price
- $907
- Updated
- 2024/03/01
Nevirapine-d4 Chemical Properties,Usage,Production
Description
Nevirapine-d4 is intended for use as an internal standard for the quantification of nevirapine by GC- or LC-MS. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50 = 0.45 μM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection. Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.
Uses
Nevirapine-d4 (cyclopropyl-2,2,3,3-d4) (CAS# 1051418-95-1) is a useful isotopically labeled research compound. This can be prepared to use as non-nucleoside reverse transcriptase inhibitors.
IC 50
HIV-1
References
[1] JAY A GROBLER. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro.[J]. The Journal of Biological Chemistry, 2007, 282 11: 8005-8010. DOI: 10.1074/jbc.m608274200
[2] PETER M. GROB. Prophylaxis against HIV-1 infection in chimpanzees by nevirapine, a nonnucleoside inhibitor of reverse transcriptase[J]. Nature Medicine, 1997, 3 6: 665-670. DOI: 10.1038/nm0697-665
Nevirapine-d4 Preparation Products And Raw materials
Raw materials
Preparation Products
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