(R)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoicacid

Product Name: (R)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoicacid
CAS No.: 86117-53-5
Chemical Name: (R)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoicacid
Synonyms: N-Tos-D-Phe-OH;Tosyl-D-phenylalanine;N-Tosyl-D-phenylalanine;N-[(4-Methylphenyl)sulfonyl]-D-phenylalanine;D-Phenylalanine, N-[(4-methylphenyl)sulfonyl]-;(R)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoicacid
CBNumber: CB02676395
Molecular Formula: C16H17NO4S
Formula Weight: 319.38
MOL File: 86117-53-5.mol

More

Less

(R)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoicacid Property

Melting point:: 164-165 °C(Solv: ethanol (64-17-5))
Boiling point:: 517.7±60.0 °C(Predicted)
Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.31±0.10(Predicted)
Appearance: White to off-white Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

AK Scientific

Product number: 5987AQ
Product name: N-TOSYL-D-PHENYLALANINE
Packaging: 100mg
Price: $158
Updated: 2021/12/16

AK Scientific

Product number: 5987AQ
Product name: N-TOSYL-D-PHENYLALANINE
Packaging: 250mg
Price: $240.8
Updated: 2021/12/16

AK Scientific

Product number: 5987AQ
Product name: N-TOSYL-D-PHENYLALANINE
Packaging: 5g
Price: $1976
Updated: 2021/12/16

Chemenu

Product number: CM255376
Product name: (R)-2-(4-Methylphenylsulfonamido)-3-phenylpropanoicacid
Purity: 97%
Packaging: 1g
Price: $270
Updated: 2021/12/16

Alichem

Product number: 86117535
Product name: (R)-2-(4-Methylphenylsulfonamido)-3-phenylpropanoicacid
Packaging: 1g
Price: $323.3
Updated: 2021/12/16

More

Less

(R)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoicacid Chemical Properties,Usage,Production

Synthesis

673-06-3

98-59-9

86117-53-5

The general procedure for the synthesis of (R)-2-(4-methylphenylsulfonylamino)-3-phenylpropanoic acid from D-phenylalanine and p-toluenesulfonyl chloride was as follows: at room temperature, D-phenylalanine (1 g, 6 mmol) was suspended in 25 mL of water, followed by the addition of NaOH (0.72 g, 18 mmol) and p-toluenesulfonyl chloride (1.37 g, 7.2 mmol). The reaction mixture was stirred at 60 °C for 6 hours. After completion of the reaction, the products were separated by acid-base washing method. This was done by adding 3M HCl and EtOAc to the reaction mixture and adjusting the pH to 1, which resulted in the protonation and transfer of D-phenylalanine to the aqueous phase, while the product was transferred to the organic phase. Subsequently, the pH was adjusted to 11-12 by adding 2M NaOH aqueous solution to deprotonate the product and transfer it back to the aqueous phase. Finally, the pH was adjusted again by adding 3M HCl to protonate the product and transfer it to the organic phase. The organic phase was washed with brine, dried with MgSO4, and the target product (1.80 g, 95% yield) was obtained by evaporating the solvent.

References

[1] Asian Journal of Chemistry, 2014, vol. 26, # 20, p. 6733 - 6736
[2] Chemistry - A European Journal, 2004, vol. 10, # 10, p. 2529 - 2547
[3] Organic Letters, 2006, vol. 8, # 4, p. 633 - 636
[4] Journal of Organic Chemistry, 2003, vol. 68, # 17, p. 6632 - 6638
[5] Chemische Berichte, 1915, vol. 48, p. 374

(R)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoicacid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(R)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoicacid Suppliers

China 30 India 2 Global 32

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

Chengdu Chuangkecheng Biological Technology Co., Ltd.

Tel: 028-028-0000000 13008177686
Fax: 15928581901
Email: sales@ckcbiotech.com
Country: China
ProdList: 904
Advantage: 55

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

Wuxi Asia Peptide Biotechnology Limited Company

Tel: 0510-83583050 13771062561
Fax: 0510-83583039
Email: willsun@peptide-search.com
Country: China
ProdList: 6716
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Kanghua (Shanghai) New Drug Development Co., Ltd.

Tel: 021-61263370 18901917034
Email: xingli@glbiochem.com
Country: China
ProdList: 5637
Advantage: 58

Shanghai Jifeng Biotechnology Co., Ltd.

Tel: 021-61263377 15023907684
Fax: 021-61263399
Email: 15800684150@163.com
Country: China
ProdList: 8131
Advantage: 58

GL Biochem (Shanghai) Ltd.

Tel: +86-021-61263370 +86-18901917034
Country: CHINA
ProdList: 3904
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

GL Biochem(Binhai) Ltd.

Tel: +86-021-61263370 +8615301650015
Email: wuqiuyan@glschina.com
Country: China
ProdList: 2975
Advantage: 58

Binhai gill polypeptide co. LTD

Tel: 021-61263389 13524856427
Fax: WeChat630417570
Email: Joetang@glschina.com
Country: China
ProdList: 10000
Advantage: 58

Guizhou Yituo Chemical Technology Co., Ltd

Tel: 18628235590
Fax: QQ:444176500
Email: wuliming@yituochem.cn
Country: China
ProdList: 1242
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo

Tel: 18584079237
Email: 312074905@qq.com
Country: China
ProdList: 2513
Advantage: 58

Gill polypeptide biopharmaceutical (dalian) co., LTD

Tel: 021-61263455 13167021076
Email: amy@glschina.com
Country: China
ProdList: 9736
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

DONBOO AMINO ACID COMPANY

Tel: +8618051385538
Email: donboo@donboo.com
Country: China
ProdList: 9363
Advantage: 58

Hubei Co-prosperity Medicine Technonlogy Co., Ltd

Tel: 2383948258 19172820304
Email: 2383948258@qq.com
Country: China
ProdList: 12987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Nanjing Wogni Chemical Co., Ltd.

Tel: 15996452985
Email: foxerhy@163.com
Country: China
ProdList: 4939
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50751
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Changzhou Xichenxi Biotechnology Co., Ltd

Tel: 13000000000
Email: 497839497@qq.com
Country: China
ProdList: 882
Advantage: 58

Shanghai Hanhong Scientific Co., Ltd.

Tel: +undefined17612118332
Email: Lucky@hanhonggroup.com
Country: China
ProdList: 5844
Advantage: 58

Aromsyn Co., Ltd.

Tel: +86-0571-85585865 +8613336024896
Email: CB@aromsyn.com
Country: China
ProdList: 19183
Advantage: 58

86117-53-5, (R)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoicacidRelated Search:

TOS-D-PRO-OH TOSYL-D-VALINE Tos-D-Glu-OH

(R)-2-(4-MethylphenylsulfonaMido)-3-phenylpropanoicacid

D-Phenylalanine, N-[(4-methylphenyl)sulfonyl]-

N-Tosyl-D-phenylalanine

Tosyl-D-phenylalanine

N-Tos-D-Phe-OH

N-[(4-Methylphenyl)sulfonyl]-D-phenylalanine

86117-53-5