Uses
ChemicalBook > CAS DataBase List > AZD-9291

AZD-9291

Uses
Product Name
AZD-9291
CAS No.
1421373-65-0
Chemical Name
AZD-9291
Synonyms
Mereletinib;N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide;ZAD9291;Osimertinib Intermediate 4;N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin;osim;CS-943;ADZ9291;Ochinib;AZD-9291
CBNumber
CB02677059
Molecular Formula
C28H33N7O2
Formula Weight
499.61
MOL File
1421373-65-0.mol
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AZD-9291 Property

Melting point:
>188oC (dec.)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka
12.68±0.70(Predicted)
form 
Solid
color 
Pale Yellow to Beige
CAS DataBase Reference
1421373-65-0
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16237
Product name
AZD 9291
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16237
Product name
AZD 9291
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
16237
Product name
AZD 9291
Purity
≥98%
Packaging
10mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
16237
Product name
AZD 9291
Purity
≥98%
Packaging
50mg
Price
$381
Updated
2024/03/01
TRC
Product number
A808075
Product name
AZD9291(Osimertinib)
Packaging
10mg
Price
$105
Updated
2021/12/16
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AZD-9291 Chemical Properties,Usage,Production

Uses

AZD-9291 (Osimertinib) is a oral, third generation, small-molecule epidermal growth factor receptor (EGFR) inhibitor and antineoplastic agent. In addition, it is a Cytochrome P450 3A inhibitor, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 1A2 Inducer, and Breast Cancer Resistance Protein Inhibitor. It is used for the treatment of advanced non-small cell lung cancer (NSCLC) where mutant EGFR form (such as T790M) is often presented. Through suppressing the EGFR-mediated signalling, it cause cell death and inhibit tumour growth in related cancer cells. 

Description

AZD-9291 (Mesylate), also known as Osimertinib, belongs to a third-generation EGFR (epidermal growth factor receptor) inhibitor. It can be used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in case when the cancer cells carry specific mutations (such as T790M) in the epidermal growth factor receptor. It takes effect through directly binding to the certain mutant forms of EGFR (T790M, L858R, and exon 19 deletions) that are frequently found in NSCLC, further causing poor prognosis for late-stage disease. Since it spares wild type EGFR during therapy, it has only limited toxicity.

Uses

AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). AZD 9291 has been shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and has been tested clinically in patients with advanced EGFR mutant non-small-cell lung cancer.[Cayman Chemical]

Definition

ChEBI: A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treat ent of EGFR T790M mutation positive non-small cell lung cancer.

Indications

The collection of ibrutinib (Imbruvica(R), Pharmacyclics Inc.), afatinib, and osimertinib represents the small, yet expanding, group of covalent SMKIs. Ibrutinib is a non-receptor Bruton’s tyrosine kinase inhibitor approved for the treatment of relapsed chronic lymphocytic leukemia. Afatinib, approved for NSCLC in 2013 and squamous NSCLC in 2016, is a second-generation irreversible EGFR inhibitor that targets wild-type EGFR, the mutant T790M EGFR, and HER2. Osimertinib (AZD9291), which was approved by FDA in November 2015, is a third-generation irreversible EGFR inhibitor that selectively targets the mutant T790M EGFR. Rociletinib, which shares a high degree of structural similarity with that of osimertinib, is a promising covalent EGFR inhibitor developed by Clovis Oncology aimed for the treatment of patients with EGFR T790M-mutated NSCLC, until the company terminated its development in May 2016 following a negative vote fromthe FDA’sOncologic Drugs Advisory Committee.

target

Exon 19 deletion EGFR

References

http://www.medkoo.com/products/6711
https://en.wikipedia.org/wiki/Osimertinib
https://www.drugbank.ca/drugs/DB09330

AZD-9291 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-9291 Suppliers

Houxu Chemical (Shandong) Co., Ltd
Tel
18295613325
Email
2026425403@qq.com
Country
China
ProdList
18
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai Prescrina Pharmaceutical Technology Co., LTD
Tel
18367323072
Email
2125193158@qq.com
Country
China
ProdList
367
Advantage
58
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
1932
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Scinova Biotech(Guangzhou) Co., Ltd.
Tel
13268215580
Email
scinova_sales@163.com
Country
China
ProdList
7023
Advantage
58
Hubei Weideli Chemical Reagent Co.,Ltd.
Tel
027-59222918 13385289472
Email
Z13385289472@163.com
Country
China
ProdList
4924
Advantage
58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
Tel
022-60182192,1339732154 18722583064
Fax
86-22-60979672
Email
marketing@pharmacn.com
Country
China
ProdList
112
Advantage
61
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
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View Lastest Price from AZD-9291 manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Azd9291 1421373-65-0
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-11-15
Cangzhou Kangrui Pharma Tech Co. Ltd.,
Product
N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 1421373-65-0
Price
US $0.00-0.00/g
Min. Order
50g
Purity
99
Supply Ability
10kg
Release date
2024-10-16
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Osimertinib,AZD9291 1421373-65-0
Price
US $0.00/g
Min. Order
1g
Purity
99%
Supply Ability
5kg/month
Release date
2021-06-19

1421373-65-0, AZD-9291Related Search:


  • N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
  • AZD929/Osimertinib
  • Osimertinib Intermediate 4
  • Osimertinib, 98%, a potent and selective mutated forms EGFR inhibitor
  • Pharmaceutical Chemical Anticancer Drug Azd-9291 for for Lung Cancer 1421373-65-0
  • Mereletinib
  • N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
  • Mereletinib mesylate(AZD9291)
  • N1-[2-(Dimethylamino)ethyl]-2-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,4-benzenetriamine
  • AZD-92941
  • CS-943
  • ADZ9291
  • Mereletinib(AZD-9291,Osimertinib)
  • EGFR INHIBITOR; AZD9291; AZD 9291;TAGRISSO
  • osim
  • EGFR INHIBITOR;AZD9291;AZD 9291;TAGRISSO;OSIMERTINIB;MERELETINIB
  • AZD9291 (free base)
  • Osimertinib (AZD-9291)
  • ZAD9291
  • AZD9291, Osimertinib
  • AZD9291 Base
  • Osimertinib Base
  • AZD9291 10G
  • N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin
  • AZD-9291
  • N(2{[2(diMethylaMino)ethyl](Methyl)aMino}4Methoxy5{[4(1Methyl1Hindol3yl)pyriMidin2yl]aMino}phenyl)prop2enaMide
  • N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
  • AZD9291,AZD-9291
  • 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-
  • AZD9291 N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
  • N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide AZD9291
  • AZD9291, >=98%
  • Ochinib
  • N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
  • )amino)-4-methoxy-5-((4-(1-methyL
  • N-(2-((2-(DimethyL
  • AZD-9291 USP/EP/BP
  • Ethanone,1-[5-bromo-3-(trifluoromethyl)-6-pyridinyl]-
  • Osimeitinib
  • Meritinib
  • Ostinidine
  • Ostinib (AZD9291)
  • 1421373-65-0
  • 421373-65-0
  • 1421273-65-0
  • C28H33N7O2
  • Inhibitors
  • API
  • Anticancer
  • AZD9291
  • 1421373-65-0