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S14161

Product Name
S14161
CAS No.
883046-50-2
Chemical Name
S14161
Synonyms
S14161;SAG Analog (LowTox);S14161, Apoptotic agent;8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran;2H-1-Benzopyran, 8-ethoxy-2-(4-fluorophenyl)-3-nitro-
CBNumber
CB02677978
Molecular Formula
C17H14FNO4
Formula Weight
315.2957632
MOL File
883046-50-2.mol
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S14161 Property

Boiling point:
456.2±45.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
color 
Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14187
Product name
S14161
Purity
≥99%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
14187
Product name
S14161
Purity
≥99%
Packaging
5mg
Price
$286
Updated
2024/03/01
Usbiological
Product number
045265
Product name
S14161
Packaging
1mg
Price
$297
Updated
2021/12/16
TRC
Product number
S080730
Product name
S14161
Packaging
10mg
Price
$340
Updated
2021/12/16
TRC
Product number
S080730
Product name
S14161
Packaging
1mg
Price
$45
Updated
2021/12/16
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S14161 Chemical Properties,Usage,Production

Description

D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.

Uses

D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.[Cayman Chemical]

Uses

S14161 is a small-molecule inhibitor of D-cyclin transactivation that displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.

storage

+4°C

S14161 Preparation Products And Raw materials

Raw materials

Preparation Products

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S14161 Suppliers

Canada 1 China 24 India 1 United Kingdom 1 United States 6 Global 33
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
NE Scientific
Tel
--
Fax
--
Country
United States
ProdList
5030
Advantage
55
Abcam
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6000
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80

883046-50-2, S14161Related Search:

Aniline

  • S14161
  • 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran
  • SAG Analog (LowTox)
  • 2H-1-Benzopyran, 8-ethoxy-2-(4-fluorophenyl)-3-nitro-
  • S14161, Apoptotic agent
  • 883046-50-2