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SIRT2 Inhibitor II, AK-1

Product Name
SIRT2 Inhibitor II, AK-1
CAS No.
330461-64-8
Chemical Name
SIRT2 Inhibitor II, AK-1
Synonyms
CS-923;AK 1, >=98%;AK-1;AK1;AK 1;AK-1 >=98% (HPLC);AK-1, 10 mM in DMSO;AK-1, SIRT2 inhibitor;SIRT2 Inhibitor II, AK-1;inhibit,AK-1,AK 1,AK1,Inhibitor,Sirtuin;Benzamide, 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-;3-(azepane-1-sulfonyl)-N-(3-nitro-phenyl)-benzamide SIRT2 Inhibitor II, AK-1
CBNumber
CB02684460
Molecular Formula
C19H21N3O5S
Formula Weight
403.45
MOL File
330461-64-8.mol
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SIRT2 Inhibitor II, AK-1 Property

storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 0.3 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
566331
Product name
SIRT2 Inhibitor II, AK-1
Purity
The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
Packaging
10 mg
Price
$150
Updated
2025/07/31
Cayman Chemical
Product number
21276
Product name
AK-1
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21276
Product name
AK-1
Packaging
10mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
21276
Product name
AK-1
Packaging
25mg
Price
$208
Updated
2024/03/01
ChemScene
Product number
CS-6310
Product name
AK-1
Purity
99.81%
Packaging
5mg
Price
$60
Updated
2021/12/16
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SIRT2 Inhibitor II, AK-1 Chemical Properties,Usage,Production

Description

AK-1 is a SIRT2 Inhibitor II that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.

Uses

AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.

IC 50

SIRT2: 12.5 μM (IC50)

References

[1] Ruth Luthi-Carter, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32. DOI:10.1073/pnas.1002924107
[2] Lee SD, et al. AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia. Cancer Lett. 2016 Apr 1;373(1):138-45. DOI:10.1016/j.canlet.2016.01.031
[3] Luthi-Carter R, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32.
[4] David M. Taylor, et al. A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase. ACS Chem Biol. 2011 Jun 17;6(6):540-6. DOI:10.1021/cb100376q
[5] Cheon MG, et al. AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. Cancer Lett. 2015 Jan 28;356(2 Pt B):637-45. DOI:10.1016/j.canlet.2014.10.012

SIRT2 Inhibitor II, AK-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SIRT2 Inhibitor II, AK-1 manufacturers

Career Henan Chemica Co
Product
SIRT2 Inhibitor II, AK-1 330461-64-8
Price
US $0.01/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1kg; 5kg; 10kg
Release date
2020-10-27

330461-64-8, SIRT2 Inhibitor II, AK-1Related Search:


  • SIRT2 Inhibitor II, AK-1
  • 3-(azepane-1-sulfonyl)-N-(3-nitro-phenyl)-benzamide SIRT2 Inhibitor II, AK-1
  • AK 1, >=98%
  • CS-923
  • AK-1;AK1;AK 1
  • Benzamide, 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-
  • AK-1 >=98% (HPLC)
  • inhibit,AK-1,AK 1,AK1,Inhibitor,Sirtuin
  • AK-1, SIRT2 inhibitor
  • AK-1, 10 mM in DMSO
  • 330461-64-8