(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL
- Product Name
- (5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL
- CAS No.
- 138090-06-9
- Chemical Name
- (5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL
- Synonyms
- R)-THC;(R,R)-THC;(R,R)THC,(R,R) THC;(R,R)-CIS-DIETHYLTETRAHYDRO-2,8-CHRYSENEDIOL;5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol;cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol;(R,R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL;(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL;2,8-Chrysenediol, 5,11-diethyl-5,6,11,12-tetrahydro-, (5R,11R)-rel-
- CBNumber
- CB0268769
- Molecular Formula
- C22H24O2
- Formula Weight
- 320.42
- MOL File
- 138090-06-9.mol
(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL Property
- Melting point:
- >189°C (dec)
- Boiling point:
- 519.0±50.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 20 mg/mL
- pka
- 10.27±0.60(Predicted)
- form
- solid
- color
- tan
- Stability:
- Light Sensitive
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 1990
- Product name
- (R,R)-THC
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $357
- Updated
- 2021/12/16
- Product number
- D445070
- Product name
- cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
- Packaging
- 50mg
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- B6909
- Product name
- (R,R)-THC
- Packaging
- 10mg
- Price
- $528
- Updated
- 2021/12/16
- Product number
- CSN22628
- Product name
- (R,R)-THC
- Packaging
- 50mg
- Price
- $644
- Updated
- 2021/12/16
(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL Chemical Properties,Usage,Production
Uses
cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a fluorescent and selective ligand that can be used to investigate the interactions between ligand and receptor of estrogen receptors (ERs) (1,2,3). cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is an ERα agonist and an ERβ antagonist.
Uses
cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a fluorescent ligands for the estrogen receptor. A series of tetrahydrochrysenes were prepared as fluorescent ligands for the estrogen receptor.
Definition
ChEBI: (R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a carbotetracyclic compound that is 5,6,11,12-tetrahydrochrysene substituted by hydroxy groups at positions 2 and 8 and by ethyl groups at positions 5 and 11 (the 5R,11R-stereoisomer). It is an agonist of ER-alpha and antagonist of ER-beta receptors. It has a role as an estrogen receptor antagonist, an estrogen receptor agonist, a geroprotector and a neuroprotective agent. It is a carbotetracyclic compound and a polyphenol.
Biological Activity
Non-steroidal, selective estrogen receptor ligand; agonist at ER α receptor (K i = 9.0 nM) and antagonist at ER β receptor (K i = 3.6 nM).
storage
Store at -20°C
(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL Preparation Products And Raw materials
Raw materials
Preparation Products
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