ChemicalBook > CAS DataBase List > NS 3623

NS 3623

Product Name: NS 3623
CAS No.: 343630-41-1
Chemical Name: NS 3623
Synonyms: NS 3623;NS3623, 10 mM in DMSO;1-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea;1-(4-Bromo-2-(1H-tetrazol-5-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea;N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea;Urea, N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]-;channels,NS 3623,midmyocardial,cardiomyocytes,current,ion,NS3623,Potassium Channel,canine,Potassium,KcsA,Inhibitor,inhibit,cells,Antiarrhythmic,effect,NS-3623
CBNumber: CB02694337
Molecular Formula: C15H10BrF3N6O
Formula Weight: 427.18
MOL File: 343630-41-1.mol

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NS 3623 Property

Density: 1.759±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble to 100 mM in DMSO
form: Powder
pka: 3.95±0.10(Predicted)
color: White to off-white
InChI: InChI=1S/C15H10BrF3N6O/c16-9-4-5-12(11(7-9)13-22-24-25-23-13)21-14(26)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H2,20,21,26)(H,22,23,24,25)
InChIKey: JXPULDIATMTIIN-UHFFFAOYSA-N
SMILES: N(C1=CC=C(Br)C=C1C1=NNN=N1)C(NC1=CC=CC(C(F)(F)F)=C1)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2843
Product name: NS3623
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $114.95
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2843
Product name: NS3623
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $489
Updated: 2025/07/31

Tocris

Product number: 4462
Product name: NS3623
Purity: ≥99%(HPLC)
Packaging: 10
Price: $233
Updated: 2021/12/16

Tocris

Product number: 4462
Product name: NS3623
Purity: ≥99%(HPLC)
Packaging: 50
Price: $980
Updated: 2021/12/16

TRC

Product number: N900250
Product name: NS3623
Packaging: 10mg
Price: $160
Updated: 2021/12/16

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NS 3623 Chemical Properties,Usage,Production

Uses

NS 3623 selectively activates the human ether-a-go-go related gene (hERG) potassium channel which mediates the repolarizing cardiac current IKr. NS 3623 an IKr agonist, cause QT interval prolongation, increasing the risk of dangerous ventricular fibrillations, eventually leading to sudden cardiac death.

Biological Activity

NS3623 is a potent and selective activator of KV11.1 (hERG) and KV4.3 channels. It activates the IKr and Ito currents and exhibits antiarrhythmic activity. NS3623 may also act as a partial blocker of KV11.1 channels.

in vivo

NS3623 (30 mg/kg; i.v.; lasting for 3 minutes) shortens the corrected QT interval by 25 +/- 4% in anaesthetized guinea pigs^[1].
NS3623 (50 mg/kg) shortenes the QT interval by 30 +/- 6% in conscious guinea pigs. NS3623 (50 mg/kg) immediately decreases the QTcF interval and remains significantly shortened for approximately 30 minutes^[1].

Animal Model:	Anesthetized guinea pig^[1]
Dosage:	30 mg/kg
Administration:	Intravenous injection; lasting for 3 minutes
Result:	Shortened the corrected QT interval by 25 +/- 4%.

storage

Store at +4°C

NS 3623 Preparation Products And Raw materials

Raw materials

Preparation Products

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NS 3623 Suppliers

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343630-41-1, NS 3623Related Search:

NS 3623

1-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea

N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea

1-(4-Bromo-2-(1H-tetrazol-5-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

channels,NS 3623,midmyocardial,cardiomyocytes,current,ion,NS3623,Potassium Channel,canine,Potassium,KcsA,Inhibitor,inhibit,cells,Antiarrhythmic,effect,NS-3623

Urea, N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]-

NS3623, 10 mM in DMSO

343630-41-1

C15H10BrF3N6O

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