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AriMocloMol Maleic Acid

Product Name
AriMocloMol Maleic Acid
CAS No.
289893-26-1
Chemical Name
AriMocloMol Maleic Acid
Synonyms
BRX220;BRX 345;BRX 220;BRX345.;BRX-345;BRX-220;AriMocloMol Maleic Acid;(2R)-Arimoclomol maleate;(2R)-Arimoclomol Maleic Acid;ARIMOCLOMOL MALEATE (BRX-220)
CBNumber
CB02695637
Molecular Formula
C18H24ClN3O7
Formula Weight
429.85206
MOL File
289893-26-1.mol
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AriMocloMol Maleic Acid Property

Melting point:
>131°C (dec.)
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Water Solubility 
H2O: 2mg/mL, clear
InChIKey
OHUSJUJCPWMZKR-FEGZNKODSA-N
SMILES
Cl/C(C1=CC=C[N+]([O-])=C1)=N\OC[C@@H](CN2CCCCC2)O.O=C(O)/C=C\C(O)=O
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A771270
Product name
(2R)-ArimoclomolMaleicAcid
Packaging
5mg
Price
$1205
Updated
2021/12/16
ChemScene
Product number
CS-0062887
Product name
Arimoclomolmaleate
Purity
99.96%
Packaging
5mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA159627
Product name
(2R)-Arimoclomol maleate
Packaging
1mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-0062887
Product name
Arimoclomolmaleate
Purity
99.96%
Packaging
10mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA159627
Product name
(2R)-Arimoclomol maleate
Packaging
2mg
Price
$100
Updated
2021/12/16
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AriMocloMol Maleic Acid Chemical Properties,Usage,Production

Uses

AriMocloMol Maleic Acid is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications.

Biological Activity

Arimoclomol is an orally available, CNS-penetrant coinducer of he at shock proteins (HSPs), notably HSP70, th at exhibits in vivo efficay in disease models of diabetes, Gaucher disease (GD), sporadic inclusion body myositis (sIBM), and neurological disorders, including amyotrophic lateral sclerosis (ALS) and Niemann-Pick disease type C1 (NPC1). Note: arimoclomol maleate and citrate salt forms are known as BRX-220 and BRX-345, respectively.

in vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1].

Animal Model:Male Wistar rats weighing 240 to 270 g[1]
Dosage:20 mg/kg
Administration:Administered intragastrically, for 5 days
Result:Had a protective effect against CCK-induced acute pancreatitis.

IC 50

HSP

AriMocloMol Maleic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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AriMocloMol Maleic Acid Suppliers

Canada 1 China 41 United Kingdom 1 United States 7 Global 50
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
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2922
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55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1112
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64
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
40000
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Wuhan Sun-shine Bio-technology Corporation Limited
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
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58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
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58

289893-26-1, AriMocloMol Maleic AcidRelated Search:


  • AriMocloMol Maleic Acid
  • (2R)-Arimoclomol Maleic Acid
  • ARIMOCLOMOL MALEATE; BRX-220; BRX 220; BRX220; BRX-345; BRX 345; BRX345.
  • BRX 220
  • BRX 345
  • BRX220
  • BRX-220
  • BRX-345
  • BRX345.
  • ARIMOCLOMOL MALEATE (BRX-220)
  • (2R)-Arimoclomol maleate
  • (R)-3-(Chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide maleate
  • Arimoclomol maleate, 10 mM in DMSO
  • 289893-26-1
  • C18H24ClN3O7
  • Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals