N-(4-Fluorobenzoyl)-5-aMino-1H-indole Property

Boiling point:

374.9±22.0 °C(Predicted)

Density 

1.374±0.06 g/cm3(Predicted)

solubility 

DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.50 mg/ml; DMSO: 16 mg/ml; Ethanol: 12.5 mg/ml

form 

A crystalline solid

pka

13.86±0.43(Predicted)

color 

Light brown to brown

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

N-(4-Fluorobenzoyl)-5-aMino-1H-indole Chemical Properties,Usage,Production

Uses

N-(4-Fluorobenzoyl)-5-amino-1H-indole is a octamer-binding transcription factor 4 activating compound that activated Oct4 and Nanog promoters, which are essential regulators of embryonic stem cell (ESC) pluripotency and key to the reprogramming process.

Uses

Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells. OAC3 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC3 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts.[Cayman Chemical]