ChemicalBook > CAS DataBase List > (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
- Product Name
- (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
- CAS No.
- 365997-33-7
- Chemical Name
- (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
- Synonyms
- Cyclohexanecarboxylic acid,3-[[(1,1-dimethylethoxy)carbonyl]...;(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester;Ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate;TIANFU CHEM-- (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester;(1S,3R,4R)-(+)-3-[(tert-Butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylic acid ethyl ester;Cyclohexanecarboxylic acid,3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-, ethyl ester,(1S,3R,4R)-
- CBNumber
- CB02703877
- Molecular Formula
- C14H25NO5
- Formula Weight
- 287.35
- MOL File
- 365997-33-7.mol
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(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester Property
- Melting point:
- 93-95°C
- Boiling point:
- 406.6±45.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 11.73±0.60(Predicted)
- color
- White to Off-White
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N-Bromosuccinimide Price
TRC
- Product number
- E927835
- Product name
- Ethyl(1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate
- Packaging
- 2.5g
- Price
- $60
- Updated
- 2021/12/16
AK Scientific
- Product number
- 9770AF
- Product name
- (1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylicacidethylester
- Packaging
- 10g
- Price
- $184
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CCH0065794
- Product name
- (1S,3R,4R)-3-(BOC-AMINO)-4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.94
- Updated
- 2021/12/16
AK Scientific
- Product number
- 9770AF
- Product name
- (1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylicacidethylester
- Packaging
- 100g
- Price
- $691
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 122061
- Product name
- (1S,3R,4R)-3-(Boc-amino)-4-hydroxy-cyclohexanecarboxylicacidethylester
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $1073
- Updated
- 2021/12/16
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(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester Chemical Properties,Usage,Production
Uses
(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester, is a building block used in various chemicla synthesis. It can be used for the preparation of six stereoisomers of diaminocyclohexane carboxamide as key intermediates for synthesis of factor Xa inhibitors.
Preparation
Under 45°C, aqueous ammonia(175 mL) was added to the (1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylate ethyl (17g, 0.1mmol). After TLC confirmed that the reaction was completed, the reaction liquid was vacuum concentrated. Then 175 mL ethanol was added to the reaction. At room temperature, di-tert-butyl dicarbonate (44.0g, 201mmol) dissolved in ethanol would be added to the above mixture. After reaction for 1h, the solid was concentrated in vacuo, and water (300 mL) was added to the mixture.The water layer was extracted with ethanol (300 mL) twice. The organic phase was collected and dried with anhydrous sodium sulfate. After vacuum concentration, the residue was purified by column chromatography on silica gel to obtain (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester.
(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester manufacturers
Career Henan Chemical Co
- Product
- (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester 365997-33-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-20
365997-33-7, (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl esterRelated Search:
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