2-(Boc-aMino)-4-Methylthiophene

2-(Boc-aMino)-4-Methylthiophene Property

Boiling point:

254.6±28.0 °C(Predicted)

Density 

1.157±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

13.63±0.70(Predicted)

Appearance

Off-white to brown Solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

2-(Boc-aMino)-4-Methylthiophene Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of tert-butyl (4-methylthiophen-2-yl)carbamate from 4-methyl-2-thiophenecarboxylate (1.00 g, 7.03 mmol) and tert-butanol: 4-methyl-2-thiophenecarboxylate (1.00 g, 7.03 mmol), diphenylphosphoryl azide (1.94 g, 7.03 mmol) and triethylamine (0.98 mL. 7.03 mmol) were dissolved in tert-butanol (20 mL) and heated to reflux for 5 hours. Upon completion of the reaction, confirmation was monitored by thin layer chromatography (unfolding agent: dichloromethane/hexane). The reaction mixture was cooled to room temperature, poured into water and extracted with ether (3 x 20 mL). The ether extracts were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a beige solid. Purification by silica gel column chromatography (eluent: hexane/dichloromethane) afforded the target compound tert-butyl (4-methylthiophen-2-yl)carbamate (0.96 g, yield 64%) as a white solid.1H-NMR (400 MHz, DMSO-d6) δ 6.42 (s, 1H), 6.35 (d, 1H), 1.46 (s, 9H).

References

[1] Patent: US2007/105864, 2007, A1. Location in patent: Page/Page column 151
[2] Patent: US2007/117804, 2007, A1. Location in patent: Page/Page column 77
[3] Patent: WO2013/78468, 2013, A1. Location in patent: Paragraph 0800