2H-Pyran-3(6H)-one
- Product Name
- 2H-Pyran-3(6H)-one
- CAS No.
- 98166-23-5
- Chemical Name
- 2H-Pyran-3(6H)-one
- Synonyms
- 6H-Pyran-3-one;2h-pyran-5-one;2H-Pyran-3(6H)-one;3,6-dihydro-2H-pyran-3-one
- CBNumber
- CB02708009
- Molecular Formula
- C5H6O2
- Formula Weight
- 98.1
- MOL File
- 98166-23-5.mol
2H-Pyran-3(6H)-one Property
- Boiling point:
- 51-53 °C(Press: 3-4 Torr)
- Density
- 1.123±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- yellow liquid
- InChI
- InChI=1S/C5H6O2/c6-5-2-1-3-7-4-5/h1-2H,3-4H2
- InChIKey
- YYRYKNXDWXDXSN-UHFFFAOYSA-N
- SMILES
- C1OCC=CC1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6867AC
- Product name
- 2H-Pyran-3(6H)-one
- Packaging
- 100mg
- Price
- $176
- Updated
- 2021/12/16
- Product number
- 6867AC
- Product name
- 2H-Pyran-3(6H)-one
- Packaging
- 250mg
- Price
- $244
- Updated
- 2021/12/16
- Product number
- CHM0388242
- Product name
- 2H-PYRAN-3(6H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.97
- Updated
- 2021/12/16
- Product number
- 6867AC
- Product name
- 2H-Pyran-3(6H)-one
- Packaging
- 1g
- Price
- $551
- Updated
- 2021/12/16
- Product number
- 6867AC
- Product name
- 2H-Pyran-3(6H)-one
- Packaging
- 5g
- Price
- $2134
- Updated
- 2021/12/16
2H-Pyran-3(6H)-one Chemical Properties,Usage,Production
Synthesis
445378-38-1
98166-23-5
General procedure for the synthesis of 2H-pyran-3(6H)-ones from 3,6-dihydro-2H-pyran-3-ol: 3,6-dihydro-2H-pyran-3-ol (2.44 g, 24.37 mmol) was dissolved in dichloromethane (100 mL) and the solution was cooled to 0 °C. Subsequently, Dess-Martin periodinane (10.34 g, 24.37 mmol) was slowly added. The reaction mixture was slowly warmed to room temperature over a period of 5 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth. After concentration of the filtrate, the crude product was purified using a 100 g SNAP Biotage column (eluent: 0-80% hexane solution of ethyl acetate) to afford 2H-pyran-3(6H)-one (2.33 g, 23.75 mmol, 97% yield) as a colorless oil.1H NMR (400 MHz, CDCl3) δ ppm: 7.07- 7.17 (m, 1H), 6.15-6.25 (m, 1H), 4.39 (t, J = 2.54 Hz, 2H), 4.19 (s, 2H).
References
[1] Patent: WO2012/145569, 2012, A1. Location in patent: Page/Page column 79; 80
[2] Angewandte Chemie - International Edition, 2005, vol. 44, # 33, p. 5306 - 5310
[3] Synlett, 2006, # 4, p. 621 - 623
[4] Patent: WO2014/134566, 2014, A2. Location in patent: Paragraph 0547
2H-Pyran-3(6H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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