Ethyl 2-iodooxazole-4-carboxylate
- Product Name
- Ethyl 2-iodooxazole-4-carboxylate
- CAS No.
- 1107663-03-5
- Chemical Name
- Ethyl 2-iodooxazole-4-carboxylate
- Synonyms
- Ethyl 2-iodooxazole-4-carboxylate;ethyl 2-iodo-1,3-oxazole-4-carboxylate;4-Oxazolecarboxylic acid, 2-iodo-, ethyl ester
- CBNumber
- CB02710354
- Molecular Formula
- C6H6INO3
- Formula Weight
- 267.02
- MOL File
- 1107663-03-5.mol
Ethyl 2-iodooxazole-4-carboxylate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 126850
- Product name
- Ethyl2-iodooxazole-4-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $1764
- Updated
- 2021/12/16
- Product number
- CM191285
- Product name
- Ethyl2-iodooxazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 61-10922
- Product name
- Ethyl2-iodooxazole-4-carboxylate
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CM191285
- Product name
- Ethyl2-iodooxazole-4-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $449
- Updated
- 2021/12/16
- Product number
- CD11351965
- Product name
- Ethyl2-iodooxazole-4-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $475
- Updated
- 2021/12/16
Ethyl 2-iodooxazole-4-carboxylate Chemical Properties,Usage,Production
Synthesis
177760-52-0
1107663-03-5
Example 25 Synthesis of ethyl 2-iodo-1,3-oxazole-4-carboxylate: 2.00 g (12.81 mmol) of ethyl 2-amino-1,3-oxazole-4-carboxylate was added to 48 ml of acetonitrile solution containing 8.00 g (38.43 mmol) of p-toluenesulfonic acid dihydrate at 0°C. Subsequently, 1.77 g (25.62 mmol) of sodium nitrite and 5.32 g (32.02 mmol) of potassium iodide dissolved in 7.2 ml of water were added dropwise to the cooled suspension. The reaction mixture was stirred at 0°C for 10 minutes before slowly warming to room temperature and continued stirring overnight. After completion of the reaction, the mixture was diluted with 200 ml of water and the pH was adjusted to 9.24 with 1 M aqueous sodium bicarbonate solution. 1 ml of 2 M sodium thiosulfate solution was added to quench the reaction. The aqueous phase was extracted three times with 30 ml of ethyl acetate, the organic phases were combined and dried with anhydrous magnesium sulfate. After filtration, the solvent was removed by rotary evaporator. The crude product was purified by column chromatography on silica gel 60 (mobile phase gradient: cyclohexane/ethyl acetate 300:1→2:1) to give 0.97 g of the target compound in 28% yield.LC-MS (Method 6): retention time Rt = 1.41 min; MS (ESIpos): m/z = 268 [M + H]+.
References
[1] Journal of the American Chemical Society, 2010, vol. 132, # 30, p. 10286 - 10292
[2] Patent: US2011/130377, 2011, A1. Location in patent: Page/Page column 24
Ethyl 2-iodooxazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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