6-chloro-2-Methoxynicotinonitrile
- Product Name
- 6-chloro-2-Methoxynicotinonitrile
- CAS No.
- 121643-46-7
- Chemical Name
- 6-chloro-2-Methoxynicotinonitrile
- Synonyms
- 6-chloro-2-Methoxynicotinonitrile;6-chloro-2-methoxypyridine-3-carbonitrile;6-chloro-2-methoxy-3-Pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-chloro-2-methoxy-
- CBNumber
- CB02712727
- Molecular Formula
- C7H5ClN2O
- Formula Weight
- 168.58
- MOL File
- 121643-46-7.mol
6-chloro-2-Methoxynicotinonitrile Property
- Boiling point:
- 272.1±35.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.30±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C597303
- Product name
- 6-Chloro-2-methoxynicotinonitrile
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 6185BB
- Product name
- 6-Chloro-2-methoxynicotinonitrile
- Packaging
- 250mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- HCH0367909
- Product name
- 6-CHLORO-2-METHOXYNICOTINONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.63
- Updated
- 2021/12/16
- Product number
- CD11327914
- Product name
- 6-Chloro-2-methoxynicotinonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $1188
- Updated
- 2021/12/16
- Product number
- CM178574
- Product name
- 6-chloro-2-methoxynicotinonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $1262
- Updated
- 2021/12/16
6-chloro-2-Methoxynicotinonitrile Chemical Properties,Usage,Production
Synthesis
67-56-1
124-41-4
40381-90-6
121643-46-7
To a stirred solution of 2,6-dichloronicotinonitrile (0.50 g, 2.89 mmol) in methanol (10 mL) was added sodium methanolate (0.62 g, 2.89 mmol) at room temperature. The reaction mixture was heated to 60 °C and stirred continuously for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. Subsequently, the reaction mixture was diluted with deionized water (40 mL) and extracted with ethyl acetate (2 x 75 mL). The organic layers were combined, washed with saturated saline (50 mL), dried over anhydrous sodium sulfate, and finally the solvent was evaporated under reduced pressure. The residue was purified by preparative high-performance liquid chromatography (HPLC) [using an Xbridge Phenyl column (21.2 × 250 mm ID, 5 μm); solvent A: 0.1% aqueous trifluoroacetic acid, solvent B: acetonitrile; gradient elution: 5-25% B, 25 min; flow rate: 20 mL/min] to afford 6-chloro-2-methoxy-3-pyridinecarbonitrile ( 0.48 g, 19% yield) as an off-white solid.1H NMR (400 MHz, CDCl3) δ ppm: 4.08 (s, 3H), 7.01-7.03 (d, J = 7.2 Hz, 1H), 7.80-7.82 (d, J = 8.0 Hz, 1H). lcms (method d): retention time 1.94 min, [M + H]+ m /z 169.2.
References
[1] Patent: WO2018/93569, 2018, A1. Location in patent: Page/Page column 100
6-chloro-2-Methoxynicotinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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