ChemicalBook > CAS DataBase List > AZD1283

AZD1283

Product Name
AZD1283
CAS No.
919351-41-0
Chemical Name
AZD1283
Synonyms
AZD1283;CS-1176;AZD1283, >98%;AZD-1283;AZD 1283;AZD1283 , CID23649325;AZD1283, 10 mM in DMSO;Ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate;ETHYL 6-(4-{[(BENZYLSULFONYL)AMINO]CARBONYL}PIPERIDIN-1-YL)-5-CYANO-2-METHYLNICOTINATE;ethyl 6-[4-(benzylsulfonylcarbamoyl)-1-piperidyl]-5-cyano-2-methyl-pyridine-3-carboxylate;6-[4-[[(Benzylsulfonyl)amino]carbonyl]piperidin-1-yl]-5-cyano-2-methylnicotinic acid ethyl ester
CBNumber
CB02715612
Molecular Formula
C23H26N4O5S
Formula Weight
470.54
MOL File
919351-41-0.mol
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AZD1283 Property

storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥18.15 mg/mL in DMSO
form 
solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2080
Product name
AZD1283
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$91.8
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2080
Product name
AZD1283
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$371
Updated
2025/07/31
Cayman Chemical
Product number
27649
Product name
AZD 1283
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
27649
Product name
AZD 1283
Packaging
25mg
Price
$381
Updated
2024/03/01
Cayman Chemical
Product number
27649
Product name
AZD 1283
Packaging
1mg
Price
$32
Updated
2024/03/01
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AZD1283 Chemical Properties,Usage,Production

Uses

AZD 1283 is a non-nucleotide reversible antagonist of P2Y12R, which regulates platelet activation and thrombus formation.

Biological Activity

the central role of the p2y12 receptor in platelet function makes it an attractive target for the development of novel antiplatelet therapies. azd1283 is found to be a potent, selective and reversible antagonist of the p2y12 receptor.

in vitro

it was observed that the benzylic azd1283 and its analogue 13 were both potent in the higher order residual platelet count assay in which the two tested 5-chlorothienyls showed low (ic50 >22 μm) potency [1].

in vivo

in a modified folts model in dog, both azd1283 and its analogue 13 could dose-dependently induce increases in blood flow and inhibition of adp-induced platelet aggregation with antithrombotic ed50 values of 3.0 and 10.0 μg/kg/min, respectively. the dose that induced a larger than 3-fold increase in bleeding time were 33 and 100 μg/kg/min for azd1283 and 13, respectively [2].

IC 50

0.011, 0.025 and 3.2 μm for binding, gtpγs and residual platelet count (rpc), respectively

storage

Store at -20°C

References

[1] bach p, antonsson t, bylund r, björkman ja, österlund k, giordanetto f, van giezen jj, andersen sm, zachrisson h, zetterberg f. lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the p2y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug azd1283. j med chem. 2013;56(17):7015-24.

AZD1283 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AZD1283 manufacturers

Career Henan Chemical Co
Product
AZD1283 919351-41-0
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

919351-41-0, AZD1283Related Search:


  • ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate AZD1283
  • ETHYL 6-(4-{[(BENZYLSULFONYL)AMINO]CARBONYL}PIPERIDIN-1-YL)-5-CYANO-2-METHYLNICOTINATE
  • AZD1283 , CID23649325
  • AZD1283
  • 6-[4-[[(Benzylsulfonyl)amino]carbonyl]piperidin-1-yl]-5-cyano-2-methylnicotinic acid ethyl ester
  • CS-1176
  • Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
  • AZD-1283;AZD 1283
  • AZD1283, >98%
  • 3-Pyridinecarboxylic acid, 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-, ethyl ester
  • P2Y Receptor,AZD-1283,thromboembolic,antiplatelet aggregation,AZD1283,inhibit,Inhibitor,antithrombotic,AZD 1283
  • ethyl 6-[4-(benzylsulfonylcarbamoyl)-1-piperidyl]-5-cyano-2-methyl-pyridine-3-carboxylate
  • Ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate
  • AZD1283, 10 mM in DMSO
  • 919351-41-0