ETP-46321

Product Name: ETP-46321
CAS No.: 1252594-99-2
Chemical Name: ETP-46321
Synonyms: CS-2500;ETP-46321;ETP46321;ETP 46321;ETP-46321, 10 mM in DMSO;Inhibitor,ETP-46321,Phosphoinositide 3-kinase,ETP46321,inhibit,PI3K,ETP 46321;5-(2-((4-methylsulfonylpiperazin-1-yl)methyl)-8-morpholinoimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-amine;5-{2-[(4-methanesulfonylpiperazin-1-yl)methyl]-8-(morpholin-4-yl)imidazo[1,2-a]pyrazin-6-yl}pyrimidin-2-amine;2-Pyrimidinamine, 5-[2-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]-
CBNumber: CB02715627
Molecular Formula: C20H27N9O3S
Formula Weight: 473.55
MOL File: 1252594-99-2.mol

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ETP-46321 Property

Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml
form: A solid
pka: 5.86±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3350
Product name: ETP-46321
Purity: 99.65%
Packaging: 5mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-3350
Product name: ETP-46321
Purity: 99.65%
Packaging: 10mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-3350
Product name: ETP-46321
Purity: 99.65%
Packaging: 50mg
Price: $1400
Updated: 2021/12/16

ChemScene

Product number: CS-3350
Product name: ETP-46321
Purity: 99.65%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

Crysdot

Product number: CD31004096
Product name: ETP-46321
Purity: 98+%
Packaging: 5mg
Price: $243
Updated: 2021/12/16

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ETP-46321 Chemical Properties,Usage,Production

Uses

ETP-46321 is a potent and orally bioavailable PI3Kα and PI3Kδ inhibitor with Kiapps of 2.3 and 14.2 nM, respectively.

in vivo

ETP-46321, is selected for in vivo studies based on its appealing pharmacokinetic profile in BALB-C mice, low in vivo Clearance (0.6 L/h/Kg) and good oral bioavailability (90%). ETP-46321 demonstrates a good pharmacokinetic profile in mice and is selected for preliminary in vivo evaluation in a lung tumor mouse model driven by a K-RasG12V oncogenic mutation, showing significant tumor growth inhibition, and reduction of the tumor metabolic activity as measured by positron emission tomography (PET) techniques^[1].

IC 50

p110α: 2.3 nM (Ki); PI3Kα-E545K: 1.77 nM (Ki); PI3Kα-E542K: 1.89 nM (Ki); PI3Kα-H1047R: 2.33 nM (Ki); p110δ: 14.2 nM (Ki); p110β: 170 nM (Ki); p110γ: 179 nM (Ki)

References

[1] Martínez González S, et al. Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor. Bioorg Med Chem Lett. 2012 May 15;22(10):3460-6. DOI:10.1016/j.bmcl.2012.03.090

ETP-46321 Preparation Products And Raw materials

Raw materials

Preparation Products

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ETP-46321 Suppliers

China 61 United States 7 Global 68

Shanghai Boyle Chemical Co., Ltd.

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LETOPHARM LIMITED

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghaizehan biopharma technology co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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1252594-99-2, ETP-46321Related Search:

ETP-46321

ETP46321;ETP 46321

CS-2500

5-(2-((4-methylsulfonylpiperazin-1-yl)methyl)-8-morpholinoimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-amine

2-Pyrimidinamine, 5-[2-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]-

Inhibitor,ETP-46321,Phosphoinositide 3-kinase,ETP46321,inhibit,PI3K,ETP 46321

5-{2-[(4-methanesulfonylpiperazin-1-yl)methyl]-8-(morpholin-4-yl)imidazo[1,2-a]pyrazin-6-yl}pyrimidin-2-amine

ETP-46321, 10 mM in DMSO

1252594-99-2

C20H27N9O3S