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LY2857785

Product Name
LY2857785
CAS No.
1619903-54-6
Chemical Name
LY2857785
Synonyms
LY2857785;LY2857785 (LY 2857785;Cyclin dependent kinase,LY 2857785,CDK,Apoptosis,LY2857785,Inhibitor,inhibit,LY-2857785;trans-N1-(4-(3-Isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine;1,4-Cyclohexanediamine, N1-[4-[2-methyl-3-(1-methylethyl)-2H-indazol-5-yl]-2-pyrimidinyl]-N4-(tetrahydro-2H-pyran-4-yl)-, trans-
CBNumber
CB02715647
Molecular Formula
C26H36N6O
Formula Weight
448.6
MOL File
1619903-54-6.mol
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LY2857785 Property

Boiling point:
671.0±65.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
insoluble in H2O; ≥13.87 mg/mL in EtOH with gentle warming; ≥2.63 mg/mL in DMSO with gentle warming and ultrasonic
form 
Powder
pka
10.05±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3336
Product name
LY2857785
Purity
98.88%
Packaging
2mg
Price
$132
Updated
2021/12/16
Axon Medchem
Product number
Axon3283
Product name
LY2857785
Purity
98%
Packaging
5mg
Price
$198
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611494
Product name
LY2857785
Packaging
5mg
Price
$385.9
Updated
2021/12/16
ChemScene
Product number
CS-3336
Product name
LY2857785
Purity
98.88%
Packaging
5mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-3336
Product name
LY2857785
Purity
98.88%
Packaging
10mg
Price
$600
Updated
2021/12/16
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LY2857785 Chemical Properties,Usage,Production

Uses

LY2857785 is a CDK9 inhibitor.

Biological Activity

ly2857785 was identified as a type i reversible and competitive atp kinase inhibitor against cdk9 and other transcription kinases cdk8 and cdk7.[1,2]cdk7 acts as a cdk-activating kinase and regulate transcription. cdk8 and cdk9 regulate transcription via phosphorylation of the rna polymerase ii carboxyl terminal domain. the cdk9-related pathway performs an important role in several biological processes, such as cell growth, proliferation, protection from apoptosis and differentiation. these kinases are reported dys-regulation in some cancers. [2]transcription activation requires phosphorylation of a carboxyl-terminal domain, by a variety of kinases including cdk7, cdk8, and cdk9. by inhibiting these kinases, ly2857785 has unique transcription inhibitor activity. ly2857785 dramatically inhibited xiap protein level in mv-4-11 and other hematologic cancer cells. it also can significantly reduce rnap ii ctd phosphorylation and dramatically decreases mcl1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines. [1]ly2857785 potently inhibits a carboxyl-terminal domain phosphorylation and exhibits antitumor efficacy in orthotopic models of leukemia. ly2857785 inhibits the growth of leukemia cells, including orthotopic leukemia preclinical models as well as in ex vivo acute myeloid leukemia and chronic lymphocytic leukemia patient tumor samples. ly2857785 may be used in treating patients with hematologic tumors, particularly aml and cll. [1]

References

[1] yin t, lallena mj, kreklau el etal. , a novel cdk9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models. mol cancer ther. 2014 jun;13(6):1442-56.
[2] romano g1, giordano a. role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases. cell cycle. 2008 dec;7(23):3664-8.

LY2857785 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY2857785 Suppliers

China 51 United States 8 Global 59
BOC Sciences
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16314854226
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info@bocsci.com
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United States
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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TargetMol Chemicals Inc.
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support@targetmol.com
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Aladdin Scientific
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+1-+1(833)-552-7181
Email
sales@aladdinsci.com
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United States
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ApexBio Technology
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United States
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Cayman Chemical Company
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Email
cayman@caymanchem.com
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United States
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United States Biological
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chemicals@usbio.net
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United States
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MedChemExpress
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1619903-54-6, LY2857785Related Search:


  • LY2857785
  • LY2857785 (LY 2857785
  • 1,4-Cyclohexanediamine, N1-[4-[2-methyl-3-(1-methylethyl)-2H-indazol-5-yl]-2-pyrimidinyl]-N4-(tetrahydro-2H-pyran-4-yl)-, trans-
  • trans-N1-(4-(3-Isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine
  • Cyclin dependent kinase,LY 2857785,CDK,Apoptosis,LY2857785,Inhibitor,inhibit,LY-2857785
  • 1619903-54-6
  • C26H36N6O