THZ1

ChemicalBook > CAS DataBase List > THZ1

Product Name: THZ1
CAS No.: 1604810-83-4
Chemical Name: THZ1
Synonyms: THZ1;CS-1233;CDK7 inhibitor;THZ1 free base;THZ1, CDK7 inhibitor;THZ-1;THZ 1;CDK7 INHIBITOR;CDK7 INHIBITOR; THZ-1; THZ 1;THZ1 HY-80013 GTPL8052 SCHEMBL14979765;(E)-N-(3-((5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-en;(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
CBNumber: CB02715672
Molecular Formula: C31H28ClN7O2
Formula Weight: 566.05
MOL File: 1604810-83-4.mol

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THZ1 Property

Density: 1.379±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥28.3 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: Powder
pka: 12.94±0.70(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 9002215
Product name: THZ1
Purity: ≥95%
Packaging: 500μg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 9002215
Product name: THZ1
Purity: ≥95%
Packaging: 1mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 9002215
Product name: THZ1
Purity: ≥95%
Packaging: 5mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 9002215
Product name: THZ1
Purity: ≥95%
Packaging: 10mg
Price: $239
Updated: 2024/03/01

TRC

Product number: T430000
Product name: THZ1
Packaging: 2.5mg
Price: $1045
Updated: 2021/12/16

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THZ1 Chemical Properties,Usage,Production

Uses

THZ1 is a covalent cyclin-dependent kinases 7 (CDK7) inhibitor. It has the ability to target a remote cysteine residue located outside of the canonical kinase domain, providing a means of achieving selectivity for CDK7.

Biological Activity

thz1 is a covalent inhibitor of cdk7 with ic50 value of 3.2nm [1].thz1 covalently modifies cdk7 by targeting c312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity. thz1 potently inhibits proliferation of jurkat and loucy t-all cell lines with ic50 values of 50nm and 0.55nm, respectively. in the kinase binding assay, thz1 shows a good binding affinity with ic50 value of 3.2nm [1].as an inhibitor of cdk7, thz1 inhibits the phosphorylation of the c-terminal domain of rnap polymerase ii, effecting the regulation of transcription. thz1 also inhibits the activation of the cdk proteins. it is reported to disrupt the cdk7 signalling pathways both in jurkat cells and loucy cells. thz1 shows a broad-based activity with ic50 values less than 200nm in a variety of cancer cell lines. among these cell lines, t-all is exceptional sensitivity to thz1 due to the transcription effect of runx1 caused by thz1 [1].

target

CDK7

References

[1] nicholas kwiatkowski, tinghu zhang, peter b. rahl et al. targeting transcription regulation in cancer with a covalent cdk7 inhibitor. nature, 2014.

THZ1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from THZ1 manufacturers

Career Henan Chemical Co

Product: THZ1 1604810-83-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-21

1604810-83-4, THZ1Related Search:

THZ1 HCl

(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide THZ1

THZ1

THZ-1;THZ 1;CDK7 INHIBITOR

N-[3-[[5-Chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]benzamide

(E)-N-(3-((5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-en

(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide

THZ1 HY-80013 GTPL8052 SCHEMBL14979765

Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-

CS-1233

THZ1, CDK7 inhibitor

CDK7 inhibitor

CDK7 INHIBITOR; THZ-1; THZ 1

THZ1 free base

THZ1 ?N-{4-[5-Chloro-4-(1H-indol-3-yl)-pyrimidin-2-ylamino]-phenyl}-4-(4-dimethylamino-but-2-enoylamino)-benzamide

(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide hydrochloride

1604810-83-4

16048-83-4

C31H28ClN7O2

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