ChemicalBook > CAS DataBase List > (S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol

(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol

Product Name
(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol
CAS No.
1234563-16-6
Chemical Name
(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol
Synonyms
AN3365;CS-2419;GSK-052;AN3365HCL;AN3365 HCl salt;AN 3365;AN-3365;Epetraborole HCl;AN3365 GSK225052;AN3365(GSK2251052);AN3365 (Epetraborole)
CBNumber
CB02722139
Molecular Formula
C11H16BNO4
Formula Weight
237.06004
MOL File
1234563-16-6.mol
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(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol Property

storage temp. 
Store at -20°C
solubility 
DMSO:200.0(Max Conc. mg/mL);731.21(Max Conc. mM)
Water:28.0(Max Conc. mg/mL);102.37(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20572
Product name
AN3365 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
20572
Product name
AN3365 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
20572
Product name
AN3365 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$266
Updated
2024/03/01
Cayman Chemical
Product number
20572
Product name
AN3365 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$573
Updated
2024/03/01
ApexBio Technology
Product number
C5068
Product name
AN3365(hydrochloride)
Packaging
25mg
Price
$608
Updated
2021/12/16
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(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol Chemical Properties,Usage,Production

Uses

Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research[1][2][3].

References

[1] Goldstein EJ, et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms. Antimicrob Agents Chemother. 2013 May;57(5):2401-4. DOI:10.1128/AAC.02580-12
[2] O'Dwyer K, et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. DOI:10.1128/AAC.03774-14
[3] Sutcliffe JA. Antibiotics in development targeting protein synthesis. Ann N Y Acad Sci. 2011 Dec;1241:122-52. DOI:10.1111/j.1749-6632.2011.06323.x

(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol Suppliers

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View Lastest Price from (S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol manufacturers

Career Henan Chemical Co
Product
Epetraborole hydrochloride 1234563-16-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

1234563-16-6, (S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-olRelated Search:

LITHIUM DIMETHYLAMIDE Hexamethyldisilazane 5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine URMC-099 CC-223 N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide

  • (S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol
  • AN3365
  • Epetraborole HCl
  • Epetraborole (hydrochloride)
  • AN 3365;AN-3365;GSK2251052;GSK 2251052;GSK-2251052
  • 3-[[(3S)-3-(Aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-1-propanol hydrochloride (1:1)
  • AN3365HCL
  • AN3365 (hydrochloride)
  • AN3365(GSK2251052)
  • AN3365 (Epetraborole)
  • AN3365 HCl salt
  • CS-2419
  • AN 3365;AN-3365
  • (S)-3-(aminomethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol hydrochloride
  • GSK2251052 hydrochloride
  • Epetraborole(GSK2251052) hydrochloride
  • 1-Propanol,3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-,hydrochloride(1:1)
  • Bacterial,GSK2251052,Epetraborole,GSK-2251052,Epetraborole hydrochloride,GSK 2251052,inhibit,Inhibitor
  • (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol HCl
  • AN3365 GSK225052
  • GSK-052
  • 1234563-16-6
  • C11H16BNO4HCl