tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate

Product Name: tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate
CAS No.: 170147-29-2
Chemical Name: tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate
Synonyms: tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate;5-Benzyloxy-indole-1-carboxylic acid tert-butyl ester;2-methyl-2-propanyl 5-(benzyloxy)-1h-indole-1-carboxylate;5-(Benzyloxy)-1H-indole-1-carboxylic acid tert-butyl ester;1H-Indole-1-carboxylic acid, 5-(phenylmethoxy)-, 1,1-dimethylethyl ester
CBNumber: CB02723404
Molecular Formula: C20H21NO3
Formula Weight: 323.39
MOL File: 170147-29-2.mol

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tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate Property

storage temp.: 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 127039
Product name: tert-Butyl5-(benzyloxy)-1H-indole-1-carboxylate
Purity: >95%
Packaging: 1g
Price: $270
Updated: 2021/12/16

Matrix Scientific

Product number: 127039
Product name: tert-Butyl5-(benzyloxy)-1H-indole-1-carboxylate
Purity: >95%
Packaging: 5g
Price: $810
Updated: 2021/12/16

Abosyn

Product number: 61-11376
Product name: tert-Butyl5-(benzyloxy)-1H-indole-1-carboxylate
Purity: 95-98%
Packaging: 5g
Price: $405
Updated: 2021/12/16

Chemenu

Product number: CM147574
Product name: tert-Butyl5-(benzyloxy)-1H-indole-1-carboxylate
Purity: 95%
Packaging: 5g
Price: $421
Updated: 2021/12/16

Crysdot

Product number: CD11239379
Product name: tert-Butyl5-(benzyloxy)-1H-indole-1-carboxylate
Purity: 95+%
Packaging: 5g
Price: $446
Updated: 2021/12/16

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tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate Chemical Properties,Usage,Production

Synthesis

1215-59-4

24424-99-5

170147-29-2

Step 1: To a solution of 5-benzyloxyindole (2 g, 8.98 mmol) in dichloromethane (DCM, 20 mL) was added sequentially triethylamine (EtsN, 3.7 mL, 26.91 mmol) and 4-dimethylaminopyridine (DMAP, 328 mg, 2.68 mmol) at 0 °C, followed by the addition of di-tert-butyl dicarbonate (Boc2O. 2.9 g, 13.45 mmol). After the addition was completed, the reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane, washed with water and saturated saline in turn, the organic phase was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to dryness. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=50:1) to afford tert-butyl 5-(benzyloxy)-1H-indole-1-carboxylate (2.5 g, yield 86.08%) as a white solid. lC/MS (ESI) m/z: 268 ([M-Boc+H]+).

References

[1] Patent: WO2007/76034, 2007, A2. Location in patent: Page/Page column 126-127
[2] Organic and Biomolecular Chemistry, 2007, vol. 5, # 8, p. 1218 - 1227
[3] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 11, p. 1689 - 1697
[4] Patent: WO2009/5998, 2009, A1. Location in patent: Page/Page column 256
[5] Chemical Communications, 2012, vol. 48, # 26, p. 3239 - 3241

tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate Suppliers

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170147-29-2, tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylateRelated Search:

tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate

2-methyl-2-propanyl 5-(benzyloxy)-1h-indole-1-carboxylate

1H-Indole-1-carboxylic acid, 5-(phenylmethoxy)-, 1,1-dimethylethyl ester

5-Benzyloxy-indole-1-carboxylic acid tert-butyl ester

5-(Benzyloxy)-1H-indole-1-carboxylic acid tert-butyl ester

170147-29-2