5-Chloro-1-Methyl-1H-pyrazol-3-aMine
- Product Name
- 5-Chloro-1-Methyl-1H-pyrazol-3-aMine
- CAS No.
- 1191453-81-2
- Chemical Name
- 5-Chloro-1-Methyl-1H-pyrazol-3-aMine
- Synonyms
- 5-Chloro-1-Methyl-1H-pyrazol-3-aMine;3-Amino-5-chloro-1-methyl-1H-pyrazole;1H-Pyrazol-3-amine, 5-chloro-1-methyl-
- CBNumber
- CB02723484
- Molecular Formula
- C4H6ClN3
- Formula Weight
- 131.56
- MOL File
- 1191453-81-2.mol
5-Chloro-1-Methyl-1H-pyrazol-3-aMine Property
- Boiling point:
- 268.0±20.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.99±0.11(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C4H6ClN3/c1-8-3(5)2-4(6)7-8/h2H,1H3,(H2,6,7)
- InChIKey
- SEVSLCCFKWIBBN-UHFFFAOYSA-N
- SMILES
- N1(C)C(Cl)=CC(N)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C369898
- Product name
- 5-Chloro-1-methyl-1H-pyrazol-3-amine
- Packaging
- 50mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 4761CZ
- Product name
- 5-Chloro-1-methyl-1H-pyrazol-3-amine
- Packaging
- 5g
- Price
- $1680
- Updated
- 2021/12/16
- Product number
- CD11335080
- Product name
- 5-Chloro-1-methyl-1H-pyrazol-3-amine
- Purity
- 95+%
- Packaging
- 10g
- Price
- $1881
- Updated
- 2021/12/16
- Product number
- 1191453812
- Product name
- 5-Chloro-1-methyl-1H-pyrazol-3-amine
- Packaging
- 5g
- Price
- $1890
- Updated
- 2021/12/16
- Product number
- 1191453812
- Product name
- 5-Chloro-1-methyl-1H-pyrazol-3-amine
- Packaging
- 10g
- Price
- $2047.67
- Updated
- 2021/12/16
5-Chloro-1-Methyl-1H-pyrazol-3-aMine Chemical Properties,Usage,Production
Synthesis
89088-52-8
1191453-81-2
5-Chloro-3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole (CAS: 89088-52-8, 0.50 g, 2.38 mmol) was used as a raw material, which was dissolved in ethanol (20 mL) in a sealed tube. Subsequently, an ethanol (5 mL) solution of hydroxylamine hydrochloride (0.83 g, 12.0 mmol) was added dropwise, followed by a water (10 mL) solution of potassium hydroxide (0.30 g, 6.0 mmol) dropwise. The reaction mixture was heated at 105 °C for 2 days, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was concentrated to remove the solvent to give the crude product. The crude product was purified by silica gel column chromatography with an eluent of 0-30% ethyl acetate-hexane mixed solvent to give 5-chloro-1-methyl-1H-pyrazol-3-amine (0.29 g, 93% yield) as a yellow liquid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (MS): 1H NMR δ 5.49 (s, 1H), 4.74 (s, 2H), 3.51 (s, 3H); MS m/z: 131.94 (M + H).
References
[1] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 000153
[2] Patent: US2009/264434, 2009, A1. Location in patent: Page/Page column 43
5-Chloro-1-Methyl-1H-pyrazol-3-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloro-1-Methyl-1H-pyrazol-3-aMine manufacturers
- Product
- 5-Chloro-1-Methyl-1H-pyrazol-3-aMine 1191453-81-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01