benzyl 2-(((benzyloxy)carbonyl)aMino)acrylate
- Product Name
- benzyl 2-(((benzyloxy)carbonyl)aMino)acrylate
- CAS No.
- 59524-07-1
- Chemical Name
- benzyl 2-(((benzyloxy)carbonyl)aMino)acrylate
- Synonyms
- benzyl 2-(((benzyloxy)carbonyl)aMino)acrylate;N-(Benxyloxycarbonyl)dehydroalanine benzyl ester;benzyl 2-{[(benzyloxy)carbonyl]amino}prop-2-enoate;2-Propenoic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, phenylmethyl ester
- CBNumber
- CB02725918
- Molecular Formula
- C18H17NO4
- Formula Weight
- 311.33
- MOL File
- 59524-07-1.mol
benzyl 2-(((benzyloxy)carbonyl)aMino)acrylate Property
- Melting point:
- 51 °C
- Boiling point:
- 459.4±45.0 °C(Predicted)
- Density
- 1.199±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.17±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1289CT
- Product name
- Benzyl2-(((benzyloxy)carbonyl)amino)acrylate
- Packaging
- 250mg
- Price
- $192
- Updated
- 2021/12/16
- Product number
- A243794
- Product name
- Benzyl2-(((benzyloxy)carbonyl)amino)acrylate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- A243794
- Product name
- Benzyl2-(((benzyloxy)carbonyl)amino)acrylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- 59524071
- Product name
- Benzyl2-(((benzyloxy)carbonyl)amino)acrylate
- Packaging
- 250mg
- Price
- $151.2
- Updated
- 2021/12/16
- Product number
- A243794
- Product name
- Benzyl2-(((benzyloxy)carbonyl)amino)acrylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $224
- Updated
- 2021/12/16
benzyl 2-(((benzyloxy)carbonyl)aMino)acrylate Chemical Properties,Usage,Production
Synthesis
40489-45-0
59524-07-1
The general procedure for the synthesis of benzyl 2-(((benzyloxy)carbonyl)amino)acrylate from benzyl ((benzyloxy)carbonyl)serine was as follows: first, 4-toluenesulfonyl chloride (TsCl) (2.0 eq.) and 4-dimethylaminopyridine (DMAP) (0.2 eq.) were added to an acetonitrile solution of N-Boc-DL-Ser-O-Me (1.0 eq.) ( 0.2 M, containing 4molecular sieves (40 mg/mmol)) and the reaction was carried out at room temperature. Subsequently, 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU) (5.0 eq.) was slowly added dropwise to the reaction mixture, and the color of the solution darkened during the dropwise addition. The reaction process was monitored by thin layer chromatography (TLC). After complete consumption of the raw materials, the reaction mixture was diluted with ethyl acetate and washed sequentially with saturated citric acid solution, water and brine. The organic phase was dried with anhydrous sodium sulfate and concentrated to obtain the crude product. Finally, the crude product was purified by fast column chromatography.
References
[1] Australian Journal of Chemistry, 1994, vol. 47, # 9, p. 1695 - 1712
[2] Synthetic Communications, 2016, vol. 46, # 11, p. 977 - 982
[3] Tetrahedron, 2007, vol. 63, # 42, p. 10534 - 10542
benzyl 2-(((benzyloxy)carbonyl)aMino)acrylate Preparation Products And Raw materials
Raw materials
Preparation Products
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