BRD4770

ChemicalBook > CAS DataBase List > BRD4770

Product Name: BRD4770
CAS No.: 1374601-40-7
Chemical Name: BRD4770
Synonyms: CS-1814;BRD4770;BRD4770 USP/EP/BP;BRD-4770; BRD 4770;Methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate;Methyl-2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate;2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate BRD4770;1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-, methyl ester
CBNumber: CB02728540
Molecular Formula: C25H23N3O3
Formula Weight: 413.47
MOL File: 1374601-40-7.mol

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BRD4770 Property

Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: 12.12±0.43(Predicted)
form: powder
color: white to beige
CAS DataBase Reference: 1374601-40-7

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0567
Product name: BRD4770
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $128
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0567
Product name: BRD4770
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $496
Updated: 2024/03/01

Cayman Chemical

Product number: 11787
Product name: BRD4770
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11787
Product name: BRD4770
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 11787
Product name: BRD4770
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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BRD4770 Chemical Properties,Usage,Production

Uses

BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 μM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both anchorage-dependent and –independent proliferation of PANC-1 cells.[Cayman Chemical]

Definition

ChEBI: 2-benzamido-1-(3-phenylpropyl)-5-benzimidazolecarboxylic acid methyl ester is a member of benzimidazoles.

Biochem/physiol Actions

BRD4770 is a selective inhibitor of the histone methyltransferase G9a. BRD4770 blocks lysine residue 9 methylation of histone H3 without inducing apoptosis. In PANC-1 cells, BRD4770 activates the ataxia telangiectasia mutated (ATM) pathway, induces senescence and inhibits anchorage-dependent and -independent growth.

BRD4770 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BRD4770 manufacturers

Career Henan Chemical Co

Product: Methyl 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate 1374601-40-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1374601-40-7, BRD4770Related Search:

BRD4770

methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate

methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate BRD4770

2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester

CS-1814

Methyl-2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate

BRD-4770; BRD 4770

Methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate

1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-, methyl ester

BRD4770 USP/EP/BP

EHMT2,G9a,BRD-4770,Histone Methyltransferase,H3K9,cell-permeable,ATR,chromatin,anti-proliferation,methylation,BRD4770,Inhibitor,BRD 4770,ATM,senescent,inhibit

1374601-40-7

Inhibitors