2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline

Product Name: 2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline
CAS No.: 590418-05-6
Chemical Name: 2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline
Synonyms: 4-Amino-3-methylphenylboronic acid, pinacol ester;2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline;2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine;Benzenamine, 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB02729633
Molecular Formula: C13H20BNO2
Formula Weight: 233.11
MOL File: 590418-05-6.mol

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2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline Property

Boiling point:: 359.0±35.0 °C(Predicted)
Density: 1.03±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 4.09±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M338045
Product name: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0005277
Product name: [2-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]AMINE
Purity: 95.00%
Packaging: 5MG
Price: $497.16
Updated: 2021/12/16

AK Scientific

Product number: J57184
Product name: 2-Methylaniline-4-boronicacidpinacolester
Packaging: 10g
Price: $600
Updated: 2021/12/16

AK Scientific

Product number: 1083AP
Product name: 2-Methylaniline-4-boronicacidpinacolester
Packaging: 10g
Price: $801
Updated: 2021/12/16

AK Scientific

Product number: J57184
Product name: 2-Methylaniline-4-boronicacidpinacolester
Packaging: 25g
Price: $1200
Updated: 2021/12/16

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2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline Chemical Properties,Usage,Production

Synthesis

583-75-5

73183-34-3

590418-05-6

General procedure for the synthesis of 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline from 2-methyl-4-bromoaniline and pinacol bis(boronic acid) ester: To a solution of 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1.05 g, 0.134 mmol) containing 4-bromo-2-methylaniline (500 mg, 2.69 mmol), potassium acetate (1.32 g, 13.4 mmol) and bis(pinacolato)diboron ( 2.05 g, 8.0 mmol) to a solution of dioxane (4 mL) was added Pd(dppf)Cl2 (110 mg, 0.134 mmol). After degassing and replacement with nitrogen, the reaction mixture was refluxed for 16 h at 85 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, water (20 mL) was added and the mixture was extracted with ethyl acetate (30 mL x 3). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated, and finally purified by silica gel column chromatography (eluent: dichloromethane) to afford the target compound 13-2 as a white solid (485 mg, 77% yield).

References

[1] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 291
[2] Patent: WO2012/104305, 2012, A1. Location in patent: Page/Page column 150
[3] Patent: EP3034078, 2016, A1. Location in patent: Paragraph 0241-0242
[4] Patent: US2005/171131, 2005, A1. Location in patent: Page/Page column 54-55
[5] Patent: US2006/25383, 2006, A1. Location in patent: Page/Page column 54

2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline Suppliers

China 49 India 2 United States 3 Global 54

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590418-05-6, 2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)anilineRelated Search:

2-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline

2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine

4-Amino-3-methylphenylboronic acid, pinacol ester

Benzenamine, 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

590418-05-6