Tefinostat

Product Name: Tefinostat
CAS No.: 914382-60-8
Chemical Name: Tefinostat
Synonyms: CHR-2845;Tefinostat;CAS:914382-60-8;Tefinostat(CHR-2845);Benzeneacetic acid, α-[[[4-[[8-(hydroxyamino)-1,8-dioxooctyl]amino]phenyl]methyl]amino]-, cyclopentyl ester, (αS)-
CBNumber: CB02730345
Molecular Formula: C28H37N3O5
Formula Weight: 495.62
MOL File: 914382-60-8.mol

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Tefinostat Property

Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 100 mg/mL (201.77 mM)
form: Solid
pka: 9.48±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0025742
Product name: Tefinostat
Purity: 98.08%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0025742
Product name: Tefinostat
Purity: 98.08%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0025742
Product name: Tefinostat
Purity: 98.08%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0025742
Product name: Tefinostat
Purity: 98.08%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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Tefinostat Chemical Properties,Usage,Production

Uses

Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias[1].

IC 50

HDAC

References

[1] Zabkiewicz J, et al. The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias. Oncotarget. 2016 Mar 29;7(13):16650-62. DOI:10.18632/oncotarget.7692

Tefinostat Preparation Products And Raw materials

Raw materials

Preparation Products

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Tefinostat Suppliers

China 30 United States 1 Global 31

Nanjing Chemlin Chemical Co., Ltd

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AN PharmaTech Co Ltd

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Pharmacodia (Beijing) Co.,Ltd

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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914382-60-8, TefinostatRelated Search:

Tefinostat

Benzeneacetic acid, α-[[[4-[[8-(hydroxyamino)-1,8-dioxooctyl]amino]phenyl]methyl]amino]-, cyclopentyl ester, (αS)-

CHR-2845

Tefinostat(CHR-2845)

CAS:914382-60-8

914382-60-8