K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine

Product Name: K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine
CAS No.: 191089-60-8
Chemical Name: K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine
Synonyms: K-7174 HCL;K-7174 2HCl;K-7174 dihydrochloride;K-7174 (hydrochloride);K 7174 dihydrochloride,K7174 dihydrochloride;K7174; K 7174; K-7174; K-7174-2HCL; K-7174 DIHYDROCHLORIDE.;1,4-Bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane;1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine;K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine
CBNumber: CB02734813
Molecular Formula: C33H48N2O6
Formula Weight: 568.76
MOL File: 191089-60-8.mol

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K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine Property

storage temp.: Store at -20°C
solubility: Water:15.0(Max Conc. mg/mL);23.38(Max Conc. mM)
form: A crystalline solid
color: White to yellow
Water Solubility: H2O: 2mg/mL, clear
InChIKey: JXXCDAKRSXICGM-AOEKMSOUSA-N
SMILES: C1CCN(CCC/C=C/C2C=C(OC)C(OC)=C(OC)C=2)CCN1CCC/C=C/C1C=C(OC)C(OC)=C(OC)C=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3105
Product name: K-7174 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $86.92
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3105
Product name: K-7174 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $295
Updated: 2025/07/31

Usbiological

Product number: 452977
Product name: K-7174 Dihydrochloride
Packaging: 100mg
Price: $523
Updated: 2021/12/16

TRC

Product number: K005000
Product name: K-7174Dihydrochloride
Packaging: 500mg
Price: $900
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611721
Product name: K-7174 dihydrochloride
Packaging: 10mg
Price: $324.7
Updated: 2021/12/16

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K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine Chemical Properties,Usage,Production

Uses

K-7174, a GATA-specific inhibitor, is a putative antiinflammatory agent that attenuates effects of inflammatory cytokines in certain cell types.

Biological Activity

K-7174 is a homopiperazine with dual GATA and proteasome inhibitory activtiy. K-7174 selective inhibts GATA-mediated gene regulations in cultures (10-30 μM; VCAM-1 expression in HUVECs or Epo suppression in Hep3B cells) and in vivo (30 mg/kg in mice via i.p. against IL-1beta- or TNF-alpha-induced anemia). K-7174 exhibits anti-myeloma activity in vitro (10-25 μM) and in vivo (50 mg/kg/day p.o. in mice) by targeting the active pockets of β1, β2 and β5 subunits of proteasome along hydrophobic grooves in the direction of the β7, β1 and β4 subunits in a manner distinct from th at of bortezomib.

in vivo

K-7174 dihydrochloride (30 mg/kg; i.p. once daily for 9 days) reverses the decreasing of hemoglobin concentrations and reticulocyte counts by IL-1β or TNF-α^[2]. K-7174 dihydrochloride (75 mg/kg; i.p. once daily for 14 days) inhibits the tumor growth in vivo^[3]. K-7174 dihydrochloride (50 mg/kg; p.o. once daily for 14 days) inhibits the tumor growth in vivo and shows a better effect than intraperitoneal injection^[3].

Animal Model:	ICR mice with IL-β or TNF-α injection^[2]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection; 30 mg/kg once daily for 9 days
Result:	Increased erythropoietin (Epo) production, reticulocyte counts, and hemoglobin (Hb) concentrations.

Animal Model:	NOD/SCID mice with murine xenograft^[3]
Dosage:	75 mg/kg
Administration:	Intraperitoneal injection; once daily for 14 days
Result:	Significantly decreased tumor volume, but showed a significant body weight reduction after 10 days.

Animal Model:	NOD/SCID mice with murine xenograft^[3]
Dosage:	50 mg/kg
Administration:	Oral gavage; once daily for 14 days
Result:	Showed an anti-myeloma activity. Porved oral administration is more effective than intraperitoneal injection.

K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine Preparation Products And Raw materials

Raw materials

Preparation Products

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K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine Suppliers

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191089-60-8, K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepineRelated Search:

K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine

K-7174 dihydrochloride

K-7174 2HCl

1,4-Bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane

K7174; K 7174; K-7174; K-7174-2HCL; K-7174 DIHYDROCHLORIDE.

1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine

K 7174 dihydrochloride,K7174 dihydrochloride

K-7174 (hydrochloride)

K-7174 HCL

191089-60-8

C33H48N2O6