ChemicalBook > CAS DataBase List > K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine

K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine

Product Name
K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine
CAS No.
191089-60-8
Chemical Name
K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine
Synonyms
K-7174 HCL;K-7174 2HCl;K-7174 dihydrochloride;K-7174 (hydrochloride);K 7174 dihydrochloride,K7174 dihydrochloride;K7174; K 7174; K-7174; K-7174-2HCL; K-7174 DIHYDROCHLORIDE.;1,4-Bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane;1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine;K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine
CBNumber
CB02734813
Molecular Formula
C33H48N2O6
Formula Weight
568.76
MOL File
191089-60-8.mol
More
Less

K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine Property

storage temp. 
Store at -20°C
solubility 
Water:15.0(Max Conc. mg/mL);23.38(Max Conc. mM)
form 
A crystalline solid
color 
White to yellow
Water Solubility 
H2O: 2mg/mL, clear
InChIKey
JXXCDAKRSXICGM-AOEKMSOUSA-N
SMILES
C1CCN(CCC/C=C/C2C=C(OC)C(OC)=C(OC)C=2)CCN1CCC/C=C/C1C=C(OC)C(OC)=C(OC)C=1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3105
Product name
K-7174 dihydrochloride
Purity
≥98% (HPLC)
Packaging
5MG
Price
$86.92
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3105
Product name
K-7174 dihydrochloride
Purity
≥98% (HPLC)
Packaging
25MG
Price
$295
Updated
2025/07/31
Usbiological
Product number
452977
Product name
K-7174 Dihydrochloride
Packaging
100mg
Price
$523
Updated
2021/12/16
TRC
Product number
K005000
Product name
K-7174Dihydrochloride
Packaging
500mg
Price
$900
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611721
Product name
K-7174 dihydrochloride
Packaging
50mg
Price
$569.5
Updated
2021/12/16
More
Less

K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine Chemical Properties,Usage,Production

Uses

K-7174, a GATA-specific inhibitor, is a putative antiinflammatory agent that attenuates effects of inflammatory cytokines in certain cell types.

Biological Activity

K-7174 is a homopiperazine with dual GATA and proteasome inhibitory activtiy. K-7174 selective inhibts GATA-mediated gene regulations in cultures (10-30 μM; VCAM-1 expression in HUVECs or Epo suppression in Hep3B cells) and in vivo (30 mg/kg in mice via i.p. against IL-1beta- or TNF-alpha-induced anemia). K-7174 exhibits anti-myeloma activity in vitro (10-25 μM) and in vivo (50 mg/kg/day p.o. in mice) by targeting the active pockets of β1, β2 and β5 subunits of proteasome along hydrophobic grooves in the direction of the β7, β1 and β4 subunits in a manner distinct from th at of bortezomib.

in vivo

K-7174 dihydrochloride (30 mg/kg; i.p. once daily for 9 days) reverses the decreasing of hemoglobin concentrations and reticulocyte counts by IL-1β or TNF-α[2]. K-7174 dihydrochloride (75 mg/kg; i.p. once daily for 14 days) inhibits the tumor growth in vivo[3]. K-7174 dihydrochloride (50 mg/kg; p.o. once daily for 14 days) inhibits the tumor growth in vivo and shows a better effect than intraperitoneal injection[3].

Animal Model:ICR mice with IL-β or TNF-α injection[2]
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg once daily for 9 days
Result:Increased erythropoietin (Epo) production, reticulocyte counts, and hemoglobin (Hb) concentrations.
Animal Model:NOD/SCID mice with murine xenograft[3]
Dosage:75 mg/kg
Administration:Intraperitoneal injection; once daily for 14 days
Result:Significantly decreased tumor volume, but showed a significant body weight reduction after 10 days.
Animal Model:NOD/SCID mice with murine xenograft[3]
Dosage:50 mg/kg
Administration:Oral gavage; once daily for 14 days
Result:Showed an anti-myeloma activity. Porved oral administration is more effective than intraperitoneal injection.

K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine Suppliers

China 56 United States 9 Global 65
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80

191089-60-8, K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepineRelated Search:


  • K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine
  • K-7174 dihydrochloride
  • K-7174 2HCl
  • 1,4-Bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane
  • K7174; K 7174; K-7174; K-7174-2HCL; K-7174 DIHYDROCHLORIDE.
  • 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine
  • K 7174 dihydrochloride,K7174 dihydrochloride
  • K-7174 (hydrochloride)
  • K-7174 HCL
  • 191089-60-8
  • C33H48N2O6