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GSK2190915

Product Name
GSK2190915
CAS No.
936350-00-4
Chemical Name
GSK2190915
Synonyms
AM 803;GSK2190915;fiboflapon;GSK2190915 (AM803);Fiboflapon (GSK2190915);Fiboflapon, 10 mM in DMSO;AM-803;FIBOFLAPON;GSK-2190915;3-(3-(tert-Butylthio)-1-(4-(6-ethoxypyridin-3-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid;1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-ethoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-[(5-methyl-2-pyridinyl)methoxy]-;3-[(1,1-Dimethylethyl)thio]-1-[[4-(6-ethoxy-3-pyridinyl)phenyl]methyl]-alpha,alpha-dimethyl-5-[(5-methyl-2-pyridinyl)methoxy]-1H-indole-2-propanoic acid
CBNumber
CB02735522
Molecular Formula
C38H43N3O4S
Formula Weight
637.83
MOL File
936350-00-4.mol
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GSK2190915 Property

Boiling point:
796.3±60.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
solubility 
DMSO: soluble; Methanol: soluble
form 
A crystalline solid
pka
4.70±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28600
Product name
GSK2190915
Packaging
1mg
Price
$110
Updated
2024/03/01
ChemScene
Product number
CS-3604
Product name
Fiboflapon
Purity
98.18%
Packaging
5mg
Price
$151
Updated
2021/12/16
AK Scientific
Product number
8831BB
Product name
Fiboflapon
Packaging
1mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-3604
Product name
Fiboflapon
Purity
98.18%
Packaging
10mg
Price
$252
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001116
Product name
AM-803
Purity
95.00%
Packaging
5MG
Price
$504.75
Updated
2021/12/16
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GSK2190915 Chemical Properties,Usage,Production

Uses

Fiboflapon (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood[1].

Definition

ChEBI: Fiboflapon is a phenylpyridine.

in vivo

Oral administration of Fiboflapon (AM-803: 1 mg/kg) results in sustained inhibition of ex vivo ionophore-challenged whole blood LTB4 biosynthesis with >90% inhibition for up to 12 h and an EC50 of approximately 7 nM. When rat lungs are challenged in vivo with calcium-ionophore, Fiboflapon (AM-803) inhibits LTB4 and cysteinyl leukotriene (CysLT) production with ED50s of 0.12 mg/kg and 0.37 mg/kg, respectively. The inhibition measured 16 h following a single oral dose of 3 mg/kg was 86% and 41% for LTB4 and CysLTs, respectively. In an acute inflammation setting, Fiboflapon dose-dependently reduced LTB4, CysLTs, plasma protein extravasation and neutrophil influx induced by peritoneal zymosan injection. Finally, Fiboflapon increases survival time in mice exposed to a lethal intravenous injection of platelet activating factor (PAF)[1].

IC 50

LTB4: 76 nM (IC50)

References

[1] Stock NS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once DOI:10.1021/jm2008369
[2] Lorrain DS, et al. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8. DOI:10.1016/j.ejphar.2010.05.003

GSK2190915 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2190915 Suppliers

CHINA 31 United States 6 Global 37
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

936350-00-4, GSK2190915Related Search:


  • GSK2190915
  • GSK2190915 (AM803)
  • fiboflapon
  • AM 803
  • 3-[(1,1-Dimethylethyl)thio]-1-[[4-(6-ethoxy-3-pyridinyl)phenyl]methyl]-alpha,alpha-dimethyl-5-[(5-methyl-2-pyridinyl)methoxy]-1H-indole-2-propanoic acid
  • AM-803;FIBOFLAPON;GSK-2190915
  • 1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-ethoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-[(5-methyl-2-pyridinyl)methoxy]-
  • Fiboflapon, 10 mM in DMSO
  • Fiboflapon (GSK2190915)
  • 3-(3-(tert-Butylthio)-1-(4-(6-ethoxypyridin-3-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
  • 936350-00-4
  • C38H43N3O4S