GS-5818 interMediate

Product Name: GS-5818 interMediate
CAS No.: 1378388-20-5
Chemical Name: GS-5818 interMediate
Synonyms: GS-5818 interMediate;3-chloro-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one;3-Chloro-10,11-dihydro-5H,9H-6-oxa-benzo[a]anthracen-8-one;3-Chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one;3-Chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-...;5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one, 3-chloro-10,11-dihydro-
CBNumber: CB02736408
Molecular Formula: C17H13ClO2
Formula Weight: 284.74
MOL File: 1378388-20-5.mol

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GS-5818 interMediate Property

storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 0465DU
Product name: 3-Chloro-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one
Packaging: 100mg
Price: $96
Updated: 2021/12/16

Ambeed

Product number: A445680
Product name: 3-Chloro-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one
Purity: 97%
Packaging: 1g
Price: $129
Updated: 2021/12/16

Crysdot

Product number: CD11269142
Product name: 3-Chloro-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one
Purity: 97%
Packaging: 250mg
Price: $238
Updated: 2021/12/16

Ambeed

Product number: A445680
Product name: 3-Chloro-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one
Purity: 97%
Packaging: 5g
Price: $352
Updated: 2021/12/16

Ambeed

Product number: A445680
Product name: 3-Chloro-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one
Purity: 97%
Packaging: 10g
Price: $548
Updated: 2021/12/16

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GS-5818 interMediate Chemical Properties,Usage,Production

Synthesis

1378388-19-2

1378388-20-5

General procedure for the synthesis of 3-chloro-10,11-dihydro-5H-dibenzo[c,g]chroman-8(9H)-one from 7-[(2-bromo-5-chlorophenyl)methoxy]-3,4-dihydro-1(2H)-naphthalenone: To a 1L flask was added palladium(II) pivalate neopentanoate (1.18 g, 3.8 mmol), tris(4-fluorophenyl)phosphine (1.20 g. 3.8 mmol), pivalic acid (2.33 g, 22.8 mmol), and potassium carbonate (31.8 g, 228 mmol), followed by a solution of 7-[(2-bromo-5-chlorophenyl)methoxy]-3,4-dihydro-1(2H)-naphthalenone (27.8 g, 76.2 mmol) in dimethylacetamide (380 mL). The flask was evacuated and backfilled with argon and the process was repeated five times. The reaction mixture was stirred at 60 °C for 24 h under argon protection. Upon completion of the reaction, it was cooled to room temperature and diluted with methyl tert-butyl ether (MTBE) and water. The resulting two-phase mixture was stirred for 3 hours, filtered through diatomaceous earth and washed with MTBE. The organic layer of the filtrate was separated and washed sequentially twice with water and once with brine. The organic layer was dried with magnesium sulfate, filtered, concentrated and purified by fast column chromatography (hexane/dichloromethane) to afford 3-chloro-10,11-dihydro-5H-dibenzo[c,g]chroman-8(9H)-one (14.4 g, 67% yield) as an off-white solid.

References

[1] Patent: WO2013/75029, 2013, A1. Location in patent: Page/Page column 53-55
[2] Patent: US2013/309196, 2013, A1. Location in patent: Paragraph 0206
[3] Patent: US2014/178336, 2014, A1. Location in patent: Paragraph 0235
[4] Patent: US2015/361073, 2015, A1. Location in patent: Paragraph 0438
[5] Patent: CN106916134, 2017, A. Location in patent: Paragraph 0013; 0023

GS-5818 interMediate Preparation Products And Raw materials

Raw materials

Preparation Products

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GS-5818 interMediate Suppliers

China 41 India 1 United States 1 Global 43

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
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Acesys Pharmatech

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Cool Pharm, Ltd

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Email: sales@coolpharm.com
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ChongQing Conscience Pharmaceuticals Ltd.

Tel: +86-023- 68549356 023-68548079
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Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

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Aikon International Limited

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Zhengzhou Acme Chemical Co., Ltd.

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Hefei TNJ Chemical Industry Co.,Ltd.

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Baoji Guokang Healthchem Co., Ltd.

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View Lastest Price from GS-5818 interMediate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 1378388-20-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 1378388-20-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 3-Chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 1378388-20-5
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-27

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GS-5818 interMediate

3-Chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one

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3-Chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-...

1378388-20-5

C17H13CIO2