ChemicalBook > CAS DataBase List > 1426129-50-1 enantioMer
1426129-50-1 enantioMer
- Product Name
- 1426129-50-1 enantioMer
- CAS No.
- 153037-40-2
- Chemical Name
- 1426129-50-1 enantioMer
- Synonyms
- LCZ-696 Impurity 66;Sacubitril Impurity 88;1426129-50-1 enantioMer;1,3-dimethyl-54-nitrosourea;Shakubatroxobin valsartan impurity 62;S-Tert-Butyl (1-([1,1'-biphenyl]-4-yl);LCZ696 valsartan + sacubitril Impurity 62;LCZ696（valsartan + sacubitril） Impurity(Hydrochloride);(2S)-2-(tert-Butoxycarbonylamino)-3-(biphenyl-4-yl)propanol;t-Butyl (S)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
- CBNumber
- CB02736569
- Molecular Formula
- C20H25NO3
- Formula Weight
- 327.42
- MOL File
- 153037-40-2.mol
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1426129-50-1 enantioMer Property
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 7184DL
- Product name
- (S)-Tert-Butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
AK Scientific
- Product number
- 7184DL
- Product name
- (S)-Tert-Butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
- Packaging
- 250mg
- Price
- $174
- Updated
- 2021/12/16
AK Scientific
- Product number
- 7184DL
- Product name
- (S)-Tert-Butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
- Packaging
- 1g
- Price
- $344
- Updated
- 2021/12/16
Ambeed
- Product number
- A220993
- Product name
- (S)-tert-Butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
Ambeed
- Product number
- A220993
- Product name
- (S)-tert-Butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
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1426129-50-1 enantioMer Chemical Properties,Usage,Production
Uses
tert-Butyl (S)-(1-([1,1'-Biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate may be useful in the preparation of tetrazolylalkylaminomethylphosphonates as neutral endopeptidase inhibitors.
Synthesis
119273-61-9
153037-40-2
GENERAL METHODS: (S)-2-(tert-butoxycarbonylamino)-3-(biphenyl-4-yl)propanoic acid (2.65 g, 10 mmol) was dissolved in tetrahydrofuran (20 mL) under nitrogen protection and the solution was cooled down to 0°C. Subsequently, triethylamine (1.42 mL, 1.1 eq.) was added to the solution and a white precipitate was observed to form.After 0.25 h, the reaction mixture was filtered. The filtrate was slowly added dropwise to a solution of sodium borohydride (0.62 g, 1.5 eq.) in water (8 mL) at 0 °C. After 0.5 h, the reaction mixture was gradually warmed up to room temperature and stirring was continued for 2 h. The reaction mixture was then stirred for 2 h. The solution was then mixed with 2M salt (1.5 mL, 1.1 eq.) and the reaction was completed with 2M salt. Upon completion of the reaction, the reaction mixture was acidified to pH=2 with 2 M hydrochloric acid and then extracted with ethyl acetate. The organic layer was subsequently washed with saturated sodium bicarbonate solution, dried over anhydrous magnesium sulfate and concentrated under vacuum to afford the target product (S)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamic acid tert-butyl ester (1.88 g, 75% yield).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1208 - 1212
1426129-50-1 enantioMer Preparation Products And Raw materials
Raw materials
Preparation Products
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