2-Chloro-3,6-dimethylpyridine
- Product Name
- 2-Chloro-3,6-dimethylpyridine
- CAS No.
- 72093-14-2
- Chemical Name
- 2-Chloro-3,6-dimethylpyridine
- Synonyms
- 2-Chloro-3,6-dimethylpyridine;Pyridine, 2-chloro-3,6-dimethyl-
- CBNumber
- CB02737263
- Molecular Formula
- C7H8ClN
- Formula Weight
- 141.6
- MOL File
- 72093-14-2.mol
2-Chloro-3,6-dimethylpyridine Property
- Boiling point:
- 45 °C(Press: 80 Torr)
- Density
- 1.113±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.71±0.10(Predicted)
- form
- liquid
- color
- Pale yellow
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C585095
- Product name
- 2-Chloro-3,6-dimethylpyridine
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- OR471325
- Product name
- 2-Chloro-3,6-dimethylpyridine
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- FC142507
- Product name
- 2-Chloro-3,6-dimethylpyridine
- Packaging
- 100mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- OR471325
- Product name
- 2-Chloro-3,6-dimethylpyridine
- Packaging
- 5g
- Price
- $412
- Updated
- 2021/12/16
- Product number
- 7945CT
- Product name
- 2-Chloro-3,6-dimethylpyridine
- Packaging
- 1g
- Price
- $438
- Updated
- 2021/12/16
2-Chloro-3,6-dimethylpyridine Chemical Properties,Usage,Production
Uses
2-Chloro-3,6-dimethylpyridine is used as a reactant in the preparation of resorcinol N-aryl amide compounds as pyruvate dehydrogenase kinase inhibitors.
Synthesis
18368-76-8
74-88-4
72093-14-2
The general procedure for the synthesis of 2-chloro-3,6-dimethylpyridine from 2-chloro-3-methylpyridine and iodomethane was as follows: n-butyllithium (1.4 M, 35.0 mL, 49.0 mmol) was slowly added to a hexane solution (15.0 mL) of 2-dimethylaminoethanol (2.15 g, 24.1 mmol) at -50 °C and stirred for 30 min. The reaction mixture was cooled to -75 °C, then a hexane (15.0 mL) solution of 2-chloro-3-methylpyridine (1.02 g, 8.0 mmol) was slowly added, ensuring that the temperature was kept below -70 °C. After 1.5 h, a THF (60.0 mL) solution of iodomethane (2.0 mL, 32.1 mmol) was slowly added, while keeping the temperature at -70 °C below. Remove the cold bath and slowly warm the mixture to 0°C. The organic layer was separated by careful addition of water (60.0 mL) for quenching and the aqueous layer was extracted with ether. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous magnesium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (25% ether/hexane as eluent) to afford the light yellow oily target compound 2-chloro-3,6-dimethylpyridine (0.674 g, 60% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 2.33 (s, 3H); 2.49 (s, 3H); 6.98 (d, 1H, J=7.5 Hz); 7.41 (d, 1H, J=7.5 Hz).
References
[1] Patent: WO2006/65204, 2006, A1. Location in patent: Page/Page column 147; 149-150
2-Chloro-3,6-dimethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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