ChemicalBook > CAS DataBase List > OTS964

OTS964

Product Name
OTS964
CAS No.
1338545-07-5
Chemical Name
OTS964
Synonyms
OTS964;CS-2531;OTS964 HCl;OTS964; OTS 964;OTS964+OTS964 HCl;OTS964 HYDROCHLORIDE;(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one;(R)-9-[4-[1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one Hydrochloride
CBNumber
CB02737339
Molecular Formula
C23H24N2O2S
Formula Weight
392.51386
MOL File
1338545-07-5.mol
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OTS964 Property

storage temp. 
Store at -20°C
solubility 
≥88.6 mg/mL in DMSO; ≥2.15 mg/mL in EtOH with gentle warming and ultrasonic; ≥2.1 mg/mL in H2O with gentle warming and ultrasonic
form 
crystalline solid
color 
Off-white to light yellow
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17052
Product name
OTS964 (hydrochloride)
Packaging
1mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
17052
Product name
OTS964 (hydrochloride)
Packaging
5mg
Price
$168
Updated
2024/03/01
Cayman Chemical
Product number
17052
Product name
OTS964 (hydrochloride)
Packaging
500μg
Price
$49
Updated
2024/03/01
TRC
Product number
O712970
Product name
OTS964
Packaging
10mg
Price
$590
Updated
2021/12/16
TRC
Product number
O712970
Product name
OTS964
Packaging
25mg
Price
$1175
Updated
2021/12/16
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OTS964 Chemical Properties,Usage,Production

Description

OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.

Uses

OTS 964 works through cytokinesis and is an effective TOPK inhibitor which has been shown to cause tumor suppression in xenografts of human cancer.

References

1. matsuo y, park jh2, miyamoto t, et al. topk inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. ci transl med. 2014 oct 22;6(259):259ra145.

OTS964 Preparation Products And Raw materials

Raw materials

Preparation Products

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OTS964 Suppliers

China 81 India 1 United States 13 Global 95
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1338545-07-5, OTS964Related Search:

CP 31398 Olaparib CP-31398 Dihydrochloride Hydrate

  • OTS964
  • (R)-9-[4-[1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one Hydrochloride
  • (R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one
  • OTS964 HYDROCHLORIDE
  • OTS964; OTS 964
  • CS-2531
  • OTS964 HCl
  • OTS964+OTS964 HCl
  • 1338545-07-5
  • C23H24N2O2SHCl
  • API