RI-2
- Product Name
- RI-2
- CAS No.
- 1417162-36-7
- Chemical Name
- RI-2
- Synonyms
- RI-2;CS-1675;RI2;RI 2;Inhibitor,RI 2,RAD51,inhibit,RI2,RI-2;1-(3,4-Dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-;1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-(morpholin-4-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
- CBNumber
- CB02744881
- Molecular Formula
- C21H18Cl2N2O4
- Formula Weight
- 433.28
- MOL File
- 1417162-36-7.mol
RI-2 Property
- Boiling point:
- 605.6±55.0 °C(Predicted)
- Density
- 1.441±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥21.65 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- -0.77±0.20(Predicted)
- color
- Yellow to orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18397
- Product name
- RI-2
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 18397
- Product name
- RI-2
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- 18397
- Product name
- RI-2
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- 18397
- Product name
- RI-2
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $1092
- Updated
- 2024/03/01
- Product number
- CS-4307
- Product name
- RI-2
- Purity
- 99.22%
- Packaging
- 5mg
- Price
- $200
- Updated
- 2021/12/16
RI-2 Chemical Properties,Usage,Production
Description
RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 μM), a protein that is central to the homologous recombination process initiated upon DNA double-
Uses
RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 μM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types. At 150 μM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro.[Cayman Chemical]
in vitro
although ri-2 did exhibit reduced activity relative to ri-1, it did retain enough activity to sensitize cells to mmc cell-based assays. ri-2 exhibited no reactivity toward glutathione after incubation for 24 hours. rad51 protein that had been treated with ri-2 prior to washing exhibited no measurable loss of dna binding activity, even though ri-2 is known to inhibit rad51 with an ic50 of 44.17 μm. this indicates that rad51 inhibition by ri-2 is fully reversible [1].
in vivo
ri-1, the analogue of ri-2, facilitated mapping of the binding pocket within known crystal structures of rad51. however, this reactivity of ri-1 potentially may limit its development in pre-clinical animal models. ri-1 has been found to exhibit a relatively short half-life, due to reactivity in thiol-containing solutions [1].
IC 50
44.17 μm
References
[1] budke b, kalin jh, pawlowski m, zelivianskaia as, wu m, kozikowski ap, connell pp. an optimized rad51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity. j med chem. 2013 jan 10;56(1):254-63.
RI-2 Preparation Products And Raw materials
Raw materials
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