RI-2

Product Name: RI-2
CAS No.: 1417162-36-7
Chemical Name: RI-2
Synonyms: RI-2;CS-1675;RI2;RI 2;Inhibitor,RI 2,RAD51,inhibit,RI2,RI-2;1-(3,4-Dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-
CBNumber: CB02744881
Molecular Formula: C21H18Cl2N2O4
Formula Weight: 433.28
MOL File: 1417162-36-7.mol

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RI-2 Property

Boiling point:: 605.6±55.0 °C(Predicted)
Density: 1.441±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥21.65 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: -0.77±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18397
Product name: RI-2
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 18397
Product name: RI-2
Purity: ≥98%
Packaging: 5mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 18397
Product name: RI-2
Purity: ≥98%
Packaging: 10mg
Price: $437
Updated: 2024/03/01

Cayman Chemical

Product number: 18397
Product name: RI-2
Purity: ≥98%
Packaging: 50mg
Price: $1092
Updated: 2024/03/01

ChemScene

Product number: CS-4307
Product name: RI-2
Purity: 99.22%
Packaging: 50mg
Price: $900
Updated: 2021/12/16

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RI-2 Chemical Properties,Usage,Production

Description

RI-2 is a reversible inhibitor of RAD51 (IC₅₀ = 44.2 μM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types. At 150 μM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro.

Uses

RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 μM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types. At 150 μM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro.[Cayman Chemical]

in vitro

although ri-2 did exhibit reduced activity relative to ri-1, it did retain enough activity to sensitize cells to mmc cell-based assays. ri-2 exhibited no reactivity toward glutathione after incubation for 24 hours. rad51 protein that had been treated with ri-2 prior to washing exhibited no measurable loss of dna binding activity, even though ri-2 is known to inhibit rad51 with an ic50 of 44.17 μm. this indicates that rad51 inhibition by ri-2 is fully reversible [1].

in vivo

ri-1, the analogue of ri-2, facilitated mapping of the binding pocket within known crystal structures of rad51. however, this reactivity of ri-1 potentially may limit its development in pre-clinical animal models. ri-1 has been found to exhibit a relatively short half-life, due to reactivity in thiol-containing solutions [1].

IC 50

44.17 μm

References

[1] budke b, kalin jh, pawlowski m, zelivianskaia as, wu m, kozikowski ap, connell pp. an optimized rad51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity. j med chem. 2013 jan 10;56(1):254-63.

RI-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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RI-2 Suppliers

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1417162-36-7, RI-2Related Search:

RI-1

RI-2

1-(3,4-Dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

CS-1675

RI2;RI 2

1H-Pyrrole-2,5-dione, 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-

Inhibitor,RI 2,RAD51,inhibit,RI2,RI-2

1417162-36-7

Inhibitors