METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE

Product Name: METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE
CAS No.: 1018446-60-0
Chemical Name: METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE
Synonyms: ethyl 5-Hydroxy-pyrazole-3-carboxylate;methyl 5-oxo-1,2-dihydropyrazole-3-carboxylate;1H-Pyrazole-3-carboxylic acid, 5-hydroxy-, methyl ester
CBNumber: CB02745439
Molecular Formula: C5H6N2O3
Formula Weight: 142.11
MOL File: 1018446-60-0.mol

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METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE Property

Boiling point:: 410.0±25.0 °C(Predicted)
Density: 1.460±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 7.91±0.23(Predicted)

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M220890
Product name: Methyl5-Hydroxy-pyrazole-3-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-0035734
Product name: Methyl5-hydroxy-1H-pyrazole-3-carboxylate
Packaging: 1g
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: 0488AA
Product name: Methyl5-hydroxy-1H-pyrazole-3-carboxylate
Packaging: 250mg
Price: $134
Updated: 2021/12/16

Apolloscientific

Product number: OR954158
Product name: Methyl5-hydroxy-pyrazole-3-carboxylate
Purity: 96%
Packaging: 1g
Price: $185
Updated: 2021/12/16

Apolloscientific

Product number: OR954158
Product name: Methyl5-hydroxy-pyrazole-3-carboxylate
Purity: 96%
Packaging: 5g
Price: $595
Updated: 2021/12/16

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METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

762-42-5

86625-25-4

General procedure for the synthesis of methyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate from dimethyl acetylenedicarboxylate: to a solution of hydrazine monohydrate (44.8 g, 894 mmol) in toluene (300 mL) was added acetic acid (180 mL), followed by the slow addition of dimethyl acetylenedicarboxylate (100 mL, 813 mmol). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was slowly poured into ice-cooled water. The resulting precipitate was collected by filtration, washed sequentially with water and hexane, and dried to afford methyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate (92.2 g, 80% yield) as a white solid. The product was characterized by 1H NMR (DMSO-d6): δ 3.77 (s, 3H), 5.96 (br s, 1H), 10.04 (br s, 1H), 12.79 (br s, 1H).

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 714 - 733
[2] Patent: WO2016/16292, 2016, A1. Location in patent: Page/Page column 55
[3] Patent: EP1362852, 2003, A1. Location in patent: Page/Page column 18
[4] Patent: WO2010/127975, 2010, A1

METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE Suppliers

China 51 India 1 United States 6 Global 58

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View Lastest Price from METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Methyl 5-Hydroxy-Pyrazole-3-Carboxylate 1018446-60-0
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-30

1018446-60-0, METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATERelated Search:

METHYL 4-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLATE Methyl 5-aMino-4-cyano-1H-pyrazole-1-carboxylate methyl 4-bromo-3-methyl-1H-pyrazole-5-carboxylate(SALTDATA: FREE) METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE METHYL 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLATE 5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Ethyl pyrazole-3-carboxylate Methyl Pyrazole-3-carboxylate 3-Amino-5-phenylpyrazole Methyl 5-broMo-1H-pyrazole-3-carboxylate 4-AMINO-2 H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER methyl 5-methoxy-1-methyl-1H-pyrazole-3-carboxylate 1H-Pyrazole-3-carboxylic acid, 4-bromo-, methyl ester

ethyl 5-Hydroxy-pyrazole-3-carboxylate

methyl 5-oxo-1,2-dihydropyrazole-3-carboxylate

1H-Pyrazole-3-carboxylic acid, 5-hydroxy-, methyl ester

1018446-60-0