ChemicalBook > CAS DataBase List > (2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Product Name
(2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.
477293-60-0
Chemical Name
(2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Synonyms
(2S,4S)-N-Boc-2-methyl-4-hydroxy-prrolidine;(2S,4S)-1-Boc-4-hydroxy-2-methylpyrrolidine;(2R,4S)-N-Boc-2-methyl-4-hydroxy-pyrrolidine;tert-butyl (2S,4S)-4-hydroxy-2-methylpyrrolidine-1-carboxylate;(2S,4S)-tert-Butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate;1,1-dimethylethyl (2S,4S)-4-hydroxy-2-methyl-1-pyrrolidinecarboxylate;(2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester;(2S,4S)-4-HYDROXY-2-METHYL-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-methyl-, 1,1-dimethylethyl ester, (2S,4S)-
CBNumber
CB02745611
Molecular Formula
C10H19NO3
Formula Weight
201.26
MOL File
477293-60-0.mol
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(2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester Property

Boiling point:
282.5±33.0 °C(Predicted)
Density 
1.094±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
14.75±0.40(Predicted)
Appearance
White to off-white Solid
optical activity
53.7° (C=0.01 g/ml, MEOH)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

AK Scientific
Product number
8583AH
Product name
(2S,4S)-tert-Butyl4-hydroxy-2-methylpyrrolidine-1-carboxylate
Packaging
250mg
Price
$177
Updated
2021/12/16
Ambeed
Product number
A628681
Product name
(2S,4S)-tert-Butyl4-hydroxy-2-methylpyrrolidine-1-carboxylate
Purity
98%
Packaging
1g
Price
$185
Updated
2021/12/16
J&W Pharmlab
Product number
75R0424
Product name
(2S,4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylicacidtert-butylester
Purity
98%
Packaging
1g
Price
$240
Updated
2021/12/16
Ambeed
Product number
A628681
Product name
(2S,4S)-tert-Butyl4-hydroxy-2-methylpyrrolidine-1-carboxylate
Purity
98%
Packaging
5g
Price
$560
Updated
2021/12/16
J&W Pharmlab
Product number
75R0424
Product name
(2S,4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylicacidtert-butylester
Purity
98%
Packaging
5g
Price
$840
Updated
2021/12/16
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(2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

1123305-80-5

477293-60-0

Step 2: Compound IV-8 (2.52 g, 7.99 mmol) was dissolved in tetrahydrofuran (13 mL). A 1 mol/L solution of tetrabutylammonium fluoride (15.97 mL, 15.97 mmol) was slowly added to this solution under cooling in an ice bath and the reaction mixture was continuously stirred at the same temperature for 10 hours. Upon completion of the reaction, water was added to the mixture and subsequently extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target compound IV-4 (1.6 g, 99.5% yield). The product was characterized by 1H-NMR (CDCl3) with chemical shifts δ: 4.42-4.39 (1H, m), 4.02-3.99 (1H, m), 3.49-3.46 (2H, m), 2.11-2.08 (1H, m), 1.76-1.73 (1H, br m), 1.57-1.53 (1H, m), 1.47 (9H , s), 1.24 (3H, t, J = 5.26 Hz).

References

[1] Patent: EP2752410, 2014, A1. Location in patent: Paragraph 0412-0413
[2] Patent: WO2009/26197, 2009, A1. Location in patent: Page/Page column 31
[3] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 2, p. 142 - 147

(2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester Suppliers

China 51 United States 4 Global 55
PharmaBlock Sciences (Nanjing),Inc.
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477293-60-0, (2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl esterRelated Search:

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  • (2S, 4S)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester
  • (2S,4S)-tert-Butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate
  • 1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-methyl-, 1,1-dimethylethyl ester, (2S,4S)-
  • tert-butyl (2S,4S)-4-hydroxy-2-methylpyrrolidine-1-carboxylate
  • (2S,4S)-4-HYDROXY-2-METHYL-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
  • 1,1-dimethylethyl (2S,4S)-4-hydroxy-2-methyl-1-pyrrolidinecarboxylate
  • (2S,4S)-1-Boc-4-hydroxy-2-methylpyrrolidine
  • (2S,4S)-N-Boc-2-methyl-4-hydroxy-prrolidine
  • (2R,4S)-N-Boc-2-methyl-4-hydroxy-pyrrolidine
  • 477293-60-0