NBI-31772 hydrate

Product Name: NBI-31772 hydrate
CAS No.: 374620-70-9
Chemical Name: NBI-31772 hydrate
Synonyms: NBI-31772 hydrate;NBI31772|||NBI 31772;NBI-31772, 10 mM in DMSO;NBI-31772 - CAS 374620-70-9 - Calbiochem;inhibit,IGF-responsive diseases,IGF-1R,IGFBP,NBI-31772,Inhibitor;1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid;3-Isoquinolinecarboxylic acid, 1-(3,4-dihydroxybenzoyl)-6,7-dihydroxy-
CBNumber: CB02750422
Molecular Formula: C17H11NO7
Formula Weight: 341.27
MOL File: 374620-70-9.mol

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NBI-31772 hydrate Property

Boiling point:: 764.7±60.0 °C(Predicted)
Density: 1.696±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.14 mg/ml
form: Greenish-yellow solid
pka: 6.68±0.20(Predicted)
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19122
Product name: NBI 31772
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19122
Product name: NBI 31772
Purity: ≥98%
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 19122
Product name: NBI 31772
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 19122
Product name: NBI 31772
Purity: ≥98%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

TRC

Product number: N381300
Product name: NBI-31772
Packaging: 10mg
Price: $325
Updated: 2021/12/16

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NBI-31772 hydrate Chemical Properties,Usage,Production

Uses

NBI-31772 is an insulin-like growth factor-I binding protein (IGFBP) ligand.

in vivo

NBI-31772 (5-100 μg; siv; administered at the onset of ischemia) dose-dependently reduces total infarct volume and cortical infarct volume at the onset of ischemia in rats with middle cerebral artery occlusion (MCAO) model^[2]. NBI-31772 (50 μg; i.v.; administered 0, 1, 2, or 3 hours after MCAO) reduces cortical infarct size and brain swelling in rats with intraluminal suture MCAO model^[2]. NBI-31772 (0.4 μM/strip; i.p.; 4 h) induces germinal vesicle rupture in zebrafish^[4].

Animal Model:	MCAO model rats^[2]
Dosage:	5, 50 and 100 μg
Administration:	siv; Drug administration during ischemic episodes
Result:	Had similar effects on total lesion volume at the 50 and 100 μg doses. Affected striatal lesion volume at the 50 μg dose.

Animal Model:	Intraluminal suture MCAO model rats^[2]
Dosage:	50 μg
Administration:	i.v.; Administration 0, 1, 2, or 3 hours after MCAO
Result:	The greatest lesion reduction was observed when the drug was administered immediately after MCAO.

storage

Store at -20°C

NBI-31772 hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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NBI-31772 hydrate Suppliers

China 42 United Kingdom 1 United States 8 USA 1 Global 52

Nanjing Chemlin Chemical Co., Ltd

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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TargetMol Chemicals Inc.

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374620-70-9, NBI-31772 hydrateRelated Search:

NBI-31772 hydrate

1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid

NBI-31772 - CAS 374620-70-9 - Calbiochem

inhibit,IGF-responsive diseases,IGF-1R,IGFBP,NBI-31772,Inhibitor

3-Isoquinolinecarboxylic acid, 1-(3,4-dihydroxybenzoyl)-6,7-dihydroxy-

NBI31772|||NBI 31772

NBI-31772, 10 mM in DMSO

374620-70-9