2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochloride

Product Name: 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochloride
CAS No.: 864249-60-5
Chemical Name: 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochloride
Synonyms: AMG-548 dihydrochloride;AMG 548;AMG-548 (AMG548);2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone;4(3H)-Pyrimidinone, 2-[[(2S)-2-amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-;2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochloride
CBNumber: CB02750503
Molecular Formula: C29H27N5O
Formula Weight: 461.56
MOL File: 864249-60-5.mol

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2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochloride Property

storage temp.: -20°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 3920
Product name: AMG548
Purity: ≥98%(HPLC)
Packaging: 10
Price: $289
Updated: 2021/12/16

TRC

Product number: A614420
Product name: AMG548
Packaging: 10mg
Price: $175
Updated: 2021/12/16

Usbiological

Product number: 254614
Product name: AMG 548
Packaging: 10mg
Price: $545
Updated: 2021/12/16

Usbiological

Product number: 145662
Product name: AMG 548
Packaging: 10mg
Price: $593
Updated: 2021/12/16

TRC

Product number: A614420
Product name: AMG548
Packaging: 50mg
Price: $795
Updated: 2021/12/16

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2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochloride Chemical Properties,Usage,Production

Uses

AMG 548 is a selective and efficacious p38 mitogen-activated protein (MAP) kinase inhibitor, which are a class of inhibitors that are investigated towards treating inflammatory diseases.

Biological Activity

amg 548 is a potent and selective inhibitor of p38α with ic50 values of 0.5, 3.6, 2600 and 4100 nm for p38α, p38β, p38γ and p38δ, respectively.p38 mitogen-activated protein kinase (p38) is a serine/threonine kinase and is responsive to a variety of cellular stresses including inflammatory cytokines, osmotic shock, ultraviolet light, lipopolysaccharides (lps) and growth factors. p38α kinase involved in the biosynthesis of tnfα and il-1β at the transcriptional and translational level [1][2].amg 548 is a potent and selective p38α inhibitor. in the antagonistic enzyme fragment complementation (efc) and β-catenin-driven luciferase (supertopflash) reporter gene assays, amg 548 inhibited wnt/β-catenin signaling, which was due to cross-reactivity with another kinase. amg 548 inhibited 17 kinases by more than 80%. in u2os-efc cells, amg 548 inhibited ckiδ and ckiε, which played an important role in the activation of wnt/b-catenin signaling. also, the concentration of amg 548 needed to inhibit ckiδ/ε in cells was closely approximate that required to inhibit wnt/b-catenin signaling in the efc and topflash assays, which suggested amg 548 inhibited wnt/b-catenin signaling mediated by the inhibition of ckiδ/ε [3].

storage

Store at -20°C

References

[1]. dominguez c, powers da, tamayo n. p38 map kinase inhibitors: many are made, but few are chosen. curr opin drug discov devel, 2005, 8(4): 421-430.
[2]. lee mr, dominguez c. map kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38alpha protein. curr med chem, 2005, 12(25): 2979-2994.
[3]. verkaar f, van der doelen aa, smits jf, et al. inhibition of wnt/β-catenin signaling by p38 map kinase inhibitors is explained by cross-reactivity with casein kinase iδ/ɛ. chem biol, 2011, 18(4): 485-494.

2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochloride Suppliers

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864249-60-5, 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochlorideRelated Search:

2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone

AMG-548 (AMG548)

2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone dihydrochloride

AMG-548 dihydrochloride

AMG 548

4(3H)-Pyrimidinone, 2-[[(2S)-2-amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-

864249-60-5