Cravatt Reagent
- Product Name
- Cravatt Reagent
- CAS No.
- 1438416-21-7
- Chemical Name
- Cravatt Reagent
- Synonyms
- KT195;KT109;HT-01;KT172;MJN110;Cravatt Reagent;MJN110 >=98% (HPLC);BEADRWVIFHOSGN-UHFFFAOYSA-N;MAGL,MJN 110,Inhibitor,Monoacylglycerol lipase,MJN110,MJN-110,inhibit;2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate
- CBNumber
- CB02750604
- Molecular Formula
- C22H21Cl2N3O4
- Formula Weight
- 462.33
- MOL File
- 1438416-21-7.mol
Cravatt Reagent Property
- Boiling point:
- 561.5±60.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 5.07±0.10(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0872
- Product name
- MJN110
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- SML0872
- Product name
- MJN110
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $194.8
- Updated
- 2024/03/01
- Product number
- 17583
- Product name
- MJN110
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $82
- Updated
- 2024/03/01
- Product number
- 17583
- Product name
- MJN110
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $808
- Updated
- 2024/03/01
- Product number
- 17583
- Product name
- MJN110
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2021/12/16
Cravatt Reagent Chemical Properties,Usage,Production
Uses
Endocannabinoids such as 2-arachidonoyl glycerol (2-AG; ) and arachidonoyl ethanolamide (AEA; ) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. MJN110 is an N-hydroxysuccinimidyl carbamate that inhibits MAGL (IC50 = 9.1 nM) and to a lesser extent ABHD6 with potent selectivity over FAAH (IC50 > 10 μM) and other brain serine hydrolases. It can inhibit 2-AG hydrolysis (IC50 = 2.1 nM) with no effect on AEA hydrolysis up to 50 μM. At 5 mg/kg, MJN110 has been shown to alleviate mechanical allodynia in a rat model of diabetic neuropathy.[Cayman Chemical]
Uses
MJN110 has been used as a monoacylglycerol lipase (MAGL) inhibitor to study its effect on aggressive grooming in rats. It has also been used to inhibit lipid droplet formation.
Biochem/physiol Actions
MJN110 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) with >10,000 selectivity over FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA). MJN110 inhibits rat, mouse and human MAGL with IC50 values ranging from < 100 nM in rat to an IC50 of ~1 nM with 10- and 100-fold selectivity over closely related ABHD6, a serine hydrolase that acts as an alternative hydrolase of 2-AG, and LYPLA1/2 in human PC3 cells. MJN110 showed potent anti-hyperalgesic activity in a rat model of diabetic neuropathy, showing a therapeutic potential for treating diabetes chronic pain.