ChemicalBook > CAS DataBase List > 2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
- Product Name
- 2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
- CAS No.
- 1395048-49-3
- Chemical Name
- 2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
- Synonyms
- M-110;CS-2124;M 110,M110;M-110 >=98% (HPLC);2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide;4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
- CBNumber
- CB02750705
- Molecular Formula
- C22H28ClN5O3
- Formula Weight
- 445.94
- MOL File
- 1395048-49-3.mol
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2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Property
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble25mg/mL, clear
- pka
- 7.46±0.40(Predicted)
- form
- powder
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0962
- Product name
- M-110
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0962
- Product name
- M-110
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $382
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-4214
- Product name
- M-110
- Purity
- 98.78%
- Packaging
- 5mg
- Price
- $195
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-4214
- Product name
- M-110
- Purity
- 98.78%
- Packaging
- 10mg
- Price
- $330
- Updated
- 2021/12/16
Crysdot
- Product number
- CD31003637
- Product name
- M-110
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $49
- Updated
- 2021/12/16
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2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Chemical Properties,Usage,Production
Biochem/physiol Actions
M-110 is a highly isoform-selective, cell permeable and potent ATP-competitive inhibitor of the PIM kinase family that prefers PIM-3. M-110 is an inhibitor of Wnt/β-catenin signaling that act downstream of the symb-catenin destruction complex to inhibit both Wnt-induced and cancer associated constitutive Wnt signaling via destabilization of β-catenin. The compound chelates iron in vitro and in intact cells. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM, with no activity on normal human peripheral blood mononuclear cells up to 40 μM.
2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Suppliers
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