2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide

Product Name: 2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
CAS No.: 1395048-49-3
Chemical Name: 2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
Synonyms: M-110;CS-2124;M 110,M110;M-110 >=98% (HPLC);M-110, 10 mM in DMSO;2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide;4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
CBNumber: CB02750705
Molecular Formula: C22H28ClN5O3
Formula Weight: 445.94
MOL File: 1395048-49-3.mol

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2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Property

Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble25mg/mL, clear
pka: 7.46±0.40(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0962
Product name: M-110
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $114.95
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0962
Product name: M-110
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $334
Updated: 2025/07/31

ChemScene

Product number: CS-4214
Product name: M-110
Purity: 98.78%
Packaging: 5mg
Price: $195
Updated: 2021/12/16

ChemScene

Product number: CS-4214
Product name: M-110
Purity: 98.78%
Packaging: 10mg
Price: $330
Updated: 2021/12/16

Crysdot

Product number: CD31003637
Product name: M-110
Purity: 98+%
Packaging: 5mg
Price: $49
Updated: 2021/12/16

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2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Chemical Properties,Usage,Production

Uses

M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM[1].

Biochem/physiol Actions

M-110 is a highly isoform-selective, cell permeable and potent ATP-competitive inhibitor of the PIM kinase family that prefers PIM-3. M-110 is an inhibitor of Wnt/β-catenin signaling that act downstream of the symb-catenin destruction complex to inhibit both Wnt-induced and cancer associated constitutive Wnt signaling via destabilization of β-catenin. The compound chelates iron in vitro and in intact cells. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM, with no activity on normal human peripheral blood mononuclear cells up to 40 μM.

References

[1] Chang M, et al.PIM kinase inhibitors downregulate STAT3(Tyr705) phosphorylation.Mol?Cancer?Ther.?2010 Sep;9(9):2478-87. DOI:10.1158/1535-7163.MCT-10-0321
[2] He Y, et al. Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways. Biochem Biophys Res Commun. 2014 Jul 4;449(3):344-50. DOI:10.1016/j.bbrc.2014.05.034
[3] Zhou E, et al. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Int Immunopharmacol. 2014 Sep;22(1):133-40. DOI:10.1016/j.intimp.2014.06.004
[4] Sa F, et al. Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo. Neurosci Lett. 2015 Apr 23;593:7-12. DOI:10.1016/j.neulet.2015.03.016
[5] Zhang LQ, et al. Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways. J Ethnopharmacol. 2015 Apr 29. pii: S0378-8741(15)00306-2. DOI:10.1016/j.jep.2015.04.040

2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Preparation Products And Raw materials

Raw materials

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2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Suppliers

China 29 United States 6 Global 35

Musechem

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TargetMol Chemicals Inc.

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Cckinase, Inc.

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BOC Sciences

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MedChemExpress

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Riedel-de Haen AG

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1395048-49-3, 2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazideRelated Search:

CS-2124

2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide

M-110

4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide

M-110 >=98% (HPLC)

M 110,M110

M-110, 10 mM in DMSO

1395048-49-3