ChemicalBook > CAS DataBase List > N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride

N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride

Product Name
N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride
CAS No.
1177798-88-7
Chemical Name
N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride
Synonyms
BRACO19 hydrochloride;BRACO19 HCl;BRACO-19 (BRACO19);BRACO19 trihydrochloride;N,N-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide Trihydrochlori;N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride;N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride
CBNumber
CB02751065
Molecular Formula
C35H44ClN7O2
Formula Weight
630.23
MOL File
1177798-88-7.mol
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N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride Property

storage temp. 
2-8°C
solubility 
H2O: soluble5mg/mL, clear
form 
powder
color 
yellow to brown
Water Solubility 
H2O: 5mg/mL, clear
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0560
Product name
BRACO19 hydrochloride
Purity
≥96% (HPLC)
Packaging
5mg
Price
$164
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0560
Product name
BRACO19 hydrochloride
Purity
≥96% (HPLC)
Packaging
25mg
Price
$660
Updated
2025/07/31
Tocris
Product number
5312
Product name
BRACO19trihydrochloride
Purity
≥95%(HPLC)
Packaging
50
Price
$852
Updated
2021/12/16
Tocris
Product number
5312
Product name
BRACO19trihydrochloride
Purity
≥95%(HPLC)
Packaging
10
Price
$203
Updated
2021/12/16
TRC
Product number
D443795
Product name
N,N''-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamideTrihydrochloride
Packaging
10mg
Price
$660
Updated
2021/12/16
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N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride Chemical Properties,Usage,Production

Uses

BRACO19 hydrochloride has been used to study the role of antiviral activity of G4-stabilizing agents in cells infected with latent human immunodeficiency virus -1 (HIV-1).

Definition

ChEBI: BRACO-19 is a hydrochloride. It contains a N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3,6-diyl)bis(3-pyrrolidin-1-ylpropanamide).

Biochem/physiol Actions

BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.

in vivo

BRACO-19 trihydrochloride (oral administration or intraperitoneal injection; 2 or 5 mg/kg; 3 weeks) oral dosing regimen are always inactive and the animals have to be sacrificed due to high tumor burden before overall termination of the study, Chronic, i.p. BRACO-19 administration, qdx5 is efficient in inhibiting tumor growth in earlystage xenografts but not advanced-stage xenografts[1]. BRACO-19 trihydrochloride (intraperitoneal injection; 2 mg/kg; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments) inhibits tumor growth significantly and under these conditions, marked single-agent antitumor activity is observed, with some animals in the group showing complete regressions (5 of 12 tumors)[1].

Animal Model:Established UXF1138LX Xenografts in nude mice[1]
Dosage:2 mg/kg
Administration:Intraperitoneal injection; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments
Result:Showed partial tumor regressions with an optimal T/C on day 28 of 4.1%, equal to 95.9% inhibition of tumor growth compared with control.

storage

Store at -20°C

N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride Suppliers

China 25 India 1 United Kingdom 1 United States 5 USA 1 Global 33
Shanghai Lollane Biological Technology Co.,Ltd.
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1177798-88-7, N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochlorideRelated Search:


  • N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride
  • BRACO19 hydrochloride
  • BRACO19 trihydrochloride
  • N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride
  • BRACO-19 (BRACO19)
  • N,N-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide Trihydrochlori
  • BRACO19 HCl
  • 1177798-88-7