ChemicalBook > CAS DataBase List > 3,5-dichloro-4-formylbenzoic acid
3,5-dichloro-4-formylbenzoic acid
- Product Name
- 3,5-dichloro-4-formylbenzoic acid
- CAS No.
- 153203-80-6
- Chemical Name
- 3,5-dichloro-4-formylbenzoic acid
- Synonyms
- Lusutrombopag Impurity 8;Lusutrombopag Impurity 4;3,5-dichloro-4-formylbenzoic acid;Ethane,1-bromo-2-(5-methoxyethoxy)-;Benzoic acid, 3,5-dichloro-4-formyl-
- CBNumber
- CB02756510
- Molecular Formula
- C8H4Cl2O3
- Formula Weight
- 219.02
- MOL File
- 153203-80-6.mol
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3,5-dichloro-4-formylbenzoic acid Property
- Boiling point:
- 366.7±42.0 °C(Predicted)
- Density
- 1.592±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 3.04±0.10(Predicted)
- color
- White to Pale Beige
- InChI
- InChI=1S/C8H4Cl2O3/c9-6-1-4(8(12)13)2-7(10)5(6)3-11/h1-3H,(H,12,13)
- InChIKey
- KNZHVHRJCNWQKI-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(Cl)=C(C=O)C(Cl)=C1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- L474988
- Product name
- 3,5-Dichloro-4-formylbenzoicAcid
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
AK Scientific
- Product number
- 6409CY
- Product name
- 3,5-Dichloro-4-formylbenzoicacid
- Packaging
- 250mg
- Price
- $88
- Updated
- 2021/12/16
Chemenu
- Product number
- CM249737
- Product name
- 3,5-Dichloro-4-formylbenzoicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $102
- Updated
- 2021/12/16
Ambeed
- Product number
- A106758
- Product name
- 3,5-Dichloro-4-formylbenzoicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $185
- Updated
- 2021/12/16
Chemenu
- Product number
- CM249737
- Product name
- 3,5-Dichloro-4-formylbenzoicacid
- Purity
- 95%
- Packaging
- 5g
- Price
- $281
- Updated
- 2021/12/16
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3,5-dichloro-4-formylbenzoic acid Chemical Properties,Usage,Production
Synthesis
51-36-5
68-12-2
153203-80-6
To the reactor was added 3,5-dichlorobenzoic acid (190 g, 1.0 mmol), which was dissolved with anhydrous THF (1 L) and cooled to -78 °C. Under the condition of maintaining the reaction temperature, n-butyllithium (2.5 M, 0.5 L) was slowly added dropwise. Subsequently, N,N-dimethylformamide (95 g, 1.3 mmol) was added slowly and the titration process lasted for 2 hours. The reaction mixture was slowly warmed up to room temperature until the feedstock completely disappeared. After completion of the reaction, the reaction was quenched with a half-saturated ammonium chloride solution and the organic phase was extracted with ethyl acetate. The organic phase was concentrated to give a white solid. Finally, purification by pulping using mixed petroleum ether/ethyl acetate solvent gave 3,5-dichloro-4-formylbenzoic acid (179 g, 82% yield).
References
[1] Patent: CN106565625, 2017, A. Location in patent: Paragraph 0073-0074
[2] Patent: CN104341316, 2017, B. Location in patent: Paragraph 0379; 0381; 0382
3,5-dichloro-4-formylbenzoic acid Preparation Products And Raw materials
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View Lastest Price from 3,5-dichloro-4-formylbenzoic acid manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 3,5-dichloro-4-formylbenzoic acid 153203-80-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2025-09-23
Henan Aochuang Chemical Co.,Ltd.
- Product
- 3,5-dichloro-4-formylbenzoic acid 153203-80-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
Shaanxi Dideu New Materials Co. Ltd
- Product
- 3,5-dichloro-4-formylbenzoic acid 153203-80-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10000kg
- Release date
- 2024-11-09
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