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HNE

Product Name
HNE
CAS No.
75899-68-2
Chemical Name
HNE
Synonyms
4-HNE;4-HYDROXYNONENAL;4-HYDROXY-2-NONENAL;(E)-4-hydroxynon-2-enal;HNE;Ccris 1781;4-hydroxy-2-nonena;(E)-4-HYDROXYNONENAL;(±)4-Hydroxynon-2-enal;4-HNE/4-Hydroxynonenal
CBNumber
CB0281140
Molecular Formula
C9H16O2
Formula Weight
156.22
MOL File
75899-68-2.mol
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HNE Property

Boiling point:
125-127 °C(Press: 2 Torr)
Density 
0.941±0.06 g/cm3(Predicted)
storage temp. 
-70°C
solubility 
DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml
pka
13.31±0.20(Predicted)
form 
Colorless oil.
color 
Colorless to light yellow
InChI
InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
InChIKey
JVJFIQYAHPMBBX-FNORWQNLSA-N
SMILES
C(=O)/C=C/C(O)CCCCC
CAS DataBase Reference
75899-68-2(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
393204
Product name
4-Hydroxynonenal-CAS75899-68-2-Calbiochem
Purity
4-Hydroxynonenal,CAS75899-68-2,isamajoraldehydeproductformedbyperoxida
Packaging
1mg
Price
$148
Updated
2025/07/31
Cayman Chemical
Product number
32100
Product name
4-hydroxy Nonenal
Purity
≥98%
Packaging
1mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
32100
Product name
4-hydroxy Nonenal
Purity
≥98%
Packaging
5mg
Price
$311
Updated
2024/03/01
Cayman Chemical
Product number
32100
Product name
4-hydroxy Nonenal
Purity
≥98%
Packaging
10mg
Price
$543
Updated
2024/03/01
Cayman Chemical
Product number
32100
Product name
4-hydroxy Nonenal
Purity
≥98%
Packaging
50mg
Price
$1912
Updated
2022/04/27
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HNE Chemical Properties,Usage,Production

Uses

4-Hydroxynonenal is an irreversible inhibitor of Na+/K+-ATPase activity.

Uses

HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 μM.[Cayman Chemical]

Definition

ChEBI: 4-hydroxynon-2-enal is an enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position. It has a role as a human metabolite. It is a hydroxyaldehyde, an enal and a 4-hydroxynonenal.

Biological Activity

Primary Target
Na+, K+-ATPase activity', 'Product does not compete with ATP.', 'Target IC50: 120 μM against Na+, K+-ATPase activity

in vivo

Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2+/+) and Nrf2-deficient mice (Nrf2-/-) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2+/+ and Nrf2-/- mice. Similar to iNOS result, in Nrf2-/- KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2+/+ WT animals[2].

IC 50

ALDH2; Human Endogenous Metabolite

HNE Preparation Products And Raw materials

Raw materials

Preparation Products

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HNE Suppliers

China 117 France 1 Germany 2 India 1 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 2 United States 21 Global 147
Spectrum Info. Ltd.
Tel
--
Fax
--
Email
spectrum@kv.ukrtel.net
Country
Ukraine
ProdList
2741
Advantage
53
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View Lastest Price from HNE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
HNE 75899-68-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

75899-68-2, HNERelated Search:

Titanium tetrachloride Glutathione 4-hydroxy Nonenal-d3 (E)-4-HYDROXY-2-NONENAL,TRANS-4-HYDROXY-2-NONENAL TRANS-4-HYDROXY-2-NONENAL-5,5,6,6,7,7,8,8,9,9,9-D11 DIMETHYL ACETAL (E)-4-HYDROXYNONENAL-DIMETHYLACETAL,(E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA,(E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA,HNE-DA,HNE-DMA (E)-4-HYDROXYNONENAL, >85% HNE INHIBITOR ANTI-HNE FLUOROPHORE TAC, CD70, CD27 Ligand, Clone: HNE.51, Mab anti-Human, FITC ANTI-HNE PAB,ANTISERUM TO (E)-4-HYDROXYNONENAL 4-Hydroxynonenal conj. BSA Purified ANTI-(E)-4-HYDROXYNONENAL,ANTI-HNE,ANTI-4-HYDROXY-2-NONENAL 4R-HYDROXY-2-NONENAL ANTI-HNE-MICHAEL ADDUCTS, REDUCED,ANTI-HNE-MICHAEL ADDUCTS, REDUCED (RABBIT),ANTI-HNE-MICHAEL ADDUCTS, REDUCED RABBIT PAB 4S-HYDROXY-2-NONENAL TAC, CD70, CD27 Ligand, Clone: HNE.51, Mab anti-Human HNE (4-Hydroxy-2-nonenal),HNE (4-Hydroxy-2-nonenal)

  • Ccris 1781
  • (E)-4-HYDROXYNONENAL
  • HNE
  • 4-HYDROXY-2-NONENAL
  • 4-HNE
  • (+/-)-4-HYDROXY-2E-NONENAL
  • (+/-)-4-HYDROXYNON-2-ENAL
  • 4-HYDROXYNONENAL
  • 4-hydroxy-2-nonena
  • (E)-4-hydroxynon-2-enal
  • 2-Nonenal, 4-hydroxy-, (2E)-
  • HNE ISO 9001：2015 REACH
  • biomarker,genotoxic,oxidative,Inhibitor,stress,Cancer,Aldehyde Dehydrogenase (ALDH),4-Hydroxynonenal,Endogenous Metabolite,4Hydroxynonenal,nitrosative,mitochondria,4 Hydroxynonenal,inhibit
  • Rabbit Anti-4 Hydroxynonenal antibody
  • Rabbit Anti-4 Hydroxynonenal/PE Conjugated antibody
  • Rabbit Anti-4 Hydroxynonenal/AF647 Conjugated antibody
  • 4-Hydroxynonenal, Lipid peroxidation marker
  • 4-Hydroxynonenal, 10 mM in DMSO
  • (±)4-Hydroxynon-2-enal
  • Mouse 4-Hydroxy-2-nonenal elisa kit
  • 4-HNE/4-Hydroxynonenal
  • 75899-68-2
  • 9001-90-6