H-D-GLU(TRP-OH)-OH

Product Name: H-D-GLU(TRP-OH)-OH
CAS No.: 229305-39-9
Chemical Name: H-D-GLU(TRP-OH)-OH
Synonyms: GLU-TRP;GolotiMod;GAMMA-GLU-TRP;Unii-637C487Y09;H-GLU(TRP-OH)-OH;H-g-D-Glu-Trp-OH;gamma-D-Glu-L-Trp;H-GAMMA-GLU-TRP-OH;H-D-GLU(TRP-OH)-OH;H-GAMMA-D-GLU-TRP-OH
CBNumber: CB0287733
Molecular Formula: C16H19N3O5
Formula Weight: 333.34
MOL File: 229305-39-9.mol

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H-D-GLU(TRP-OH)-OH Property

Boiling point:: 737.3±60.0 °C(Predicted)
Density: 1.428±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: Soluble in DMSO
pka: 2.22±0.10(Predicted)
form: Solid
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: AAA0001316
Product name: GAMMA-D-GLU-TRP-OH
Purity: 95.00%
Packaging: 25MG
Price: $588.19
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0001316
Product name: GAMMA-D-GLU-TRP-OH
Purity: 95.00%
Packaging: 100MG
Price: $681.57
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0001316
Product name: GAMMA-D-GLU-TRP-OH
Purity: 95.00%
Packaging: 250MG
Price: $848.93
Updated: 2021/12/16

DC Chemicals

Product number: DC26017
Product name: Golotimod(SCV-07)
Purity: >98%
Packaging: 100mg
Price: $400
Updated: 2021/12/16

Chemenu

Product number: CM265202
Product name: (R)-2-Amino-5-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoicacid
Purity: 97%
Packaging: 1g
Price: $542
Updated: 2021/12/16

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H-D-GLU(TRP-OH)-OH Chemical Properties,Usage,Production

Uses

Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2)[1][2][3].

Definition

ChEBI: Golotimod is a dipeptide.

in vivo

Golotimod (SCV-07) (oral gavage or subcutaneous injection, 100 μg/kg, 5 days) reduces experimental recurrent genital HSV-2 disease by oral administration, more importantly, oral SCV07 after fasting shows a greater reduction in incidence and severity than SCV-07 without fasting in female hartley guinea pigs^[1].
Golotimod (SCV-07) (subcutaneous injection, once or twice a day from days 1 to 20, 100 μg/kg) can reduce the severity and duration of acute and split radiation-induced oral mucositis (OM) and short the duration of ulcerative OM in male LVG golden Syrian Hamsters^[3].

Animal Model:	Female Hartley guinea pigs (250-300 g) infected HSV-2^[1]
Dosage:	100 μg/kg
Administration:	Oral gavage or subcutaneous injection; 5 days
Result:	Reduced incidence of lesions from 55% (one week before treatment) to only 18% by oral administration, and showed no significant reduction in disease by subcutaneous injection of SCV-07.

Animal Model:	Male LVG golden Syrian Hamsters weighing approximately 80 g with radiation-induced mucositis^[3]
Dosage:	10, 100 μg/kg or 1 mg/kg
Administration:	Subcutaneous injection; once or twice a day from days 1 to 20
Result:	Showed a peak mucositis of 3.0 on day 18 in the control group compared to only 2.2 in the test group, and the mucositis score in the SCV-07 treated hamsters was only 6.3% compared to 28.1% in the control group at dose of 100 μg/kg. Significantly decreased the severity and duration of oral mucositis (OM) at dose of 10 μg/kg, 100 μg/kg or 1 mg/kg.

IC 50

STAT3

References

[1] Rose WA 2nd, et al. An immunomodulating dipeptide, SCV-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2). Int J Antimicrob Agents. 2008 Sep;32(3):262-6. DOI:10.1016/j.ijantimicag.2008.04.010
[2] Geiger JL, et al. The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations. Oral Oncol. 2016 May;56:84-92. DOI:10.1016/j.oraloncology.2015.11.022
[3] Watkins B, et al. Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Dis. 2010 Oct;16(7):655-60. DOI:10.1111/j.1601-0825.2010.01671.x

H-D-GLU(TRP-OH)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-D-GLU(TRP-OH)-OH Suppliers

China 56 Japan 1 Switzerland 1 United States 8 Global 66

Shanghai Boyle Chemical Co., Ltd.

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View Lastest Price from H-D-GLU(TRP-OH)-OH manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: H-D-GLU(TRP-OH)-OH 229305-39-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: H-D-GLU(TRP-OH)-OH 229305-39-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

Career Henan Chemical Co

Product: H-D-GLU(TRP-OH)-OH 229305-39-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

229305-39-9, H-D-GLU(TRP-OH)-OHRelated Search:

H-GLU-TRP-OH H-GAMMA-GLU-ALA-OH H-GAMMA-GLU-GLY-OH 2-amino-4-(propan-2-ylcarbamoyl)butanoic acid H-GAMMA-GLU-ABU-OH H-D-GLU(TRP-OH)-OH Octapeptide-11 Oligopeptide-36 H-SER-PHE-LEU-LEU-ARG-NH2 Decapeptide-20

H-g-D-Glu-Trp-OH

gamma-D-Glu-L-Trp

Unii-637C487Y09

GLU-TRP

GAMMA-GLU-TRP

H-D-GLU(TRP-OH)-OH

H-GAMMA-GLU-TRP-OH

H-GAMMA-D-GLU-TRP-OH

H-GLU(TRP-OH)-OH

(2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid

GolotiMod

H-g-D-Glu-Trp-OH, GolotiMod, BestiM

GOLOTIMOD (UNII-637C487Y09)

gammaDglutamylLtryptophan

SCV 07; SCV-07; SCV07; GAMMADGLUTAMYLLTRYPTOPHAN

L-Tryptophan, D-γ-glutamyl-

H-D-Glu(L-Trp-OH)-OH

Gamma-D-glutamyl-L-tryptophan|||SCV 07

229305-39-9

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical

Dipeptides and Tripeptides

Dipeptides