PIRONETIN
- Product Name
- PIRONETIN
- CAS No.
- 151519-02-7
- Chemical Name
- PIRONETIN
- Synonyms
- PIRONETIN;2H-Pyran-2-one, 5-ethyl-5,6-dihydro-6-[(2R,3S,4R,5S,7E)-2-hydroxy-4-methoxy-3,5-dimethyl-7-nonen-1-yl]-, (5R,6R)-
- CBNumber
- CB0303174
- Molecular Formula
- C19H32O4
- Formula Weight
- 324.45
- MOL File
- 151519-02-7.mol
PIRONETIN Property
- Melting point:
- 75-77 °C
- Boiling point:
- 473.1±40.0 °C(Predicted)
- Density
- 0.993±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Dichloromethane: soluble; DMSO: soluble; Ethanol: soluble
- form
- A solid
- pka
- 14.28±0.20(Predicted)
- color
- Colorless to off-white
Safety
- HS Code
- 29419000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
N-Bromosuccinimide Price
- Product number
- 28853
- Product name
- Pironetin
- Packaging
- 1mg
- Price
- $242
- Updated
- 2024/03/01
- Product number
- BIBR1078
- Product name
- Pironetin
- Packaging
- 1mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- INB0002625
- Product name
- PIRONETIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.52
- Updated
- 2021/12/16
- Product number
- CS-0065506
- Product name
- Pironetin
- Packaging
- 1mg
- Price
- $1500
- Updated
- 2021/12/16
PIRONETIN Chemical Properties,Usage,Production
Uses
Pironetin is an α/β unsaturated lactone isolated from Streptomyces species. Pironetin binds to α-tubulin and is a potent inhibitor of microtubule polymerization, and has cell cycle arrest and antitumor activity[1][2].
Definition
ChEBI: Pironetin is an aliphatic alcohol.
in vivo
Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment shows a moderate antitumor effect, however, a severe weight loss is observed as a side effect[1].
| Animal Model: | Female CDF1-SLC mice (10 weeks) injected with P388 murine leukemia cells[1] |
| Dosage: | 0.78 mg/kg, 1.56 mg/kg, 3.13 mg/kg, 6.25 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 5 days |
| Result: | Showed a moderate antitumor effect. |
References
[1] Kondoh M, et al. Cell cycle arrest and antitumor activity of pironetin and its derivatives. Cancer Lett. 1998 Apr 10;126(1):29-32. DOI:10.1016/s0304-3835(97)00528-4
[2] Yang J, et al. Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule. ] Nat Commun. 2016 Jun 30;7:12103. DOI:10.1038/ncomms12103
PIRONETIN Preparation Products And Raw materials
Raw materials
Preparation Products
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