Methyl 2-bromoquinoline-4-carboxylate
- Product Name
- Methyl 2-bromoquinoline-4-carboxylate
- CAS No.
- 103502-48-3
- Chemical Name
- Methyl 2-bromoquinoline-4-carboxylate
- Synonyms
- Methyl 2-bromo-4-quinolinecarboxylate;Methyl 2-bromoquinoline-4-carboxylate;2-bromo-quinoline-4-carboxylic acid methyl ester;4-Quinolinecarboxylic acid, 2-bromo-, methyl ester
- CBNumber
- CB03037694
- Molecular Formula
- C11H8BrNO2
- Formula Weight
- 266.09
- MOL File
- 103502-48-3.mol
Methyl 2-bromoquinoline-4-carboxylate Property
- Melting point:
- 93.5-94.5 °C
- Boiling point:
- 351.0±22.0 °C(Predicted)
- Density
- 1.557±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.70±0.50(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M296708
- Product name
- Methyl2-Bromoquinoline-4-carboxylate
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 9701CV
- Product name
- Methyl2-bromoquinoline-4-carboxylate
- Packaging
- 5g
- Price
- $802
- Updated
- 2021/12/16
- Product number
- CD11362155
- Product name
- Methyl2-bromoquinoline-4-carboxylate
- Purity
- 97%
- Packaging
- 10g
- Price
- $891
- Updated
- 2021/12/16
- Product number
- CM259426
- Product name
- Methyl2-bromoquinoline-4-carboxylate
- Purity
- 95%
- Packaging
- 25g
- Price
- $1309
- Updated
- 2021/12/16
- Product number
- CD11362155
- Product name
- Methyl2-bromoquinoline-4-carboxylate
- Purity
- 97%
- Packaging
- 25g
- Price
- $1782
- Updated
- 2021/12/16
Methyl 2-bromoquinoline-4-carboxylate Chemical Properties,Usage,Production
Synthesis
39497-01-3
103502-48-3
General procedure for the synthesis of methyl 2-bromoquinoline-4-carboxylate from methyl 2-oxo-1,2-dihydroquinoline-4-carboxylate: 0.203 g of methyl 2-hydroxyquinoline-4-carboxylate (1 mmol) was dissolved in 20 ml of anhydrous toluene, followed by the addition of 0.356 mg of P2O5 (2.5 mmol). The reaction mixture was heated to 100°C and kept for 2 hours. After completion of the reaction, it was cooled to room temperature and the toluene layer was washed with 25 ml of saturated NaHCO3 solution and then with 25 ml of brine. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated to give a light yellow solid product in 89% yield (0.237 g). The product was characterized by 1H NMR (DMSO-d6, 500MHz): δ 4.00 (s, 3H), 7.81 (td, 1H, J = 7.2Hz).
References
[1] Patent: WO2012/6068, 2012, A2. Location in patent: Page/Page column 65-66
Methyl 2-bromoquinoline-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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