BC2059

Product Name: BC2059
CAS No.: 1227637-23-1
Chemical Name: BC2059
Synonyms: BC2059;Tegavivint;Tegoprazan D6;BC-2059 Te atrabetan;Tegatrabetan (BC2059);BC-2059;BC2059;TEGAVIVINT;TEGATRABETAN;BC-2059;TEGAVIVINT;Tegatrabetan,inhibit,Inhibitor,β-catenin,BC-2059,Beta catenin,BC 2059;rel-2,7-Bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime;9,10-Anthracenedione, 2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-, 9,10-dioxime, rel-
CBNumber: CB03038499
Molecular Formula: C28H36N4O6S2
Formula Weight: 588.74
MOL File: 1227637-23-1.mol

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BC2059 Property

Boiling point:: 757.6±70.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 125 mg/mL (212.32 mM)
pka: 10.07±0.20(Predicted)
form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0039507
Product name: Tegatrabetan
Purity: 98.19%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0039507
Product name: Tegatrabetan
Purity: 98.19%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0039507
Product name: Tegatrabetan
Purity: 98.19%
Packaging: 50mg
Price: $430
Updated: 2021/12/16

DC Chemicals

Product number: DC20756
Product name: Tegatrabetan
Purity: >98%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

DC Chemicals

Product number: DC20756
Product name: Tegatrabetan
Purity: >98%
Packaging: 1g
Price: $2500
Updated: 2021/12/16

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BC2059 Chemical Properties,Usage,Production

Biological Activity

Tegatrabetan (BC2059) is a beta-Catenin antagonist. It disrupts β-catenin binding to scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and reduces β-catenin nuclear levels.

in vivo

Tegatrabetan (BC2059; 1.0 or 5.0 mg/kg/day; intravenously) significantly improves the median survival of the mice from approximately 17.5 to 39 days. Treatment with Tegatrabetan (10 mg/kg/day; intravenously) alone further improves the median survival to 51.5 days.

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Animal Model:	NOD/SCID mice bearing OCI-AML3 xenografts
Dosage:	1 mg/kg; 5 mg/kg; 10 mg/kg
Administration:	Intravenously; 1 mg/kg daily 4 days per week or 5 mg/kg or 10 mg/kg of BC2059 twice per week (Tuesday and Thursday) for 3 weeks.
Result:	Treatment significantly improved survival of NOD/SCID mice bearing OCI-AML3 xenografts.

target

Target	Value
β-catenin ()

BC2059 Preparation Products And Raw materials

Raw materials

Preparation Products

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BC2059 Suppliers

China 23 India 1 United States 5 Global 29

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1227637-23-1, BC2059Related Search:

BC2059

BC-2059;BC2059;TEGAVIVINT

Tegavivint

TEGATRABETAN;BC-2059;TEGAVIVINT

9,10-Anthracenedione, 2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-, 9,10-dioxime, rel-

rel-2,7-Bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime

Tegatrabetan (BC2059)

Tegatrabetan,inhibit,Inhibitor,β-catenin,BC-2059,Beta catenin,BC 2059

Tegoprazan D6

BC-2059 Te atrabetan

1227637-23-1