ChemicalBook > CAS DataBase List > JP 1302 2HCl

JP 1302 2HCl

Product Name
JP 1302 2HCl
CAS No.
1259314-65-2
Chemical Name
JP 1302 2HCl
Synonyms
JP-1302 HCl;JP 1302 2HCl;JP-1302 (hydrochloride);JP1302 dihydrochloride, 10 mM in DMSO;JP1302 dihydrochloride, alpha2C antagonist;N-(4-(4-Methylpiperazin-1-yl)phenyl)acridin-9-amine dihydrochloride;Inhibitor,JP 1302,JP-1302,JP1302 dihydrochloride,inhibit,JP1302,Beta Receptor,Adrenergic Receptor,JP-1302 dihydrochloride
CBNumber
CB03038505
Molecular Formula
C24H25ClN4
Formula Weight
404.94
MOL File
1259314-65-2.mol
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JP 1302 2HCl Property

storage temp. 
Store at -20°C
solubility 
Soluble to 100 mM in water and to 5 mM in DMSO
form 
Powder
color 
Brown to reddish brown
Water Solubility 
Soluble to 100 mM in water
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
J212010
Product name
JP1302Dihydrochloride
Packaging
10mg
Price
$160
Updated
2021/12/16
ChemScene
Product number
CS-0025304
Product name
JP1302dihydrochloride
Purity
99.83%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0025304
Product name
JP1302dihydrochloride
Purity
99.83%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0025304
Product name
JP1302dihydrochloride
Purity
99.83%
Packaging
50mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0025304
Product name
JP1302dihydrochloride
Purity
99.83%
Packaging
100mg
Price
$750
Updated
2021/12/16
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JP 1302 2HCl Chemical Properties,Usage,Production

Uses

JP 1302 Dihydrochloride is an α2-adrenoceptor blocker and can be used for the treatment or prevention of nephropathy.

in vivo

JP1302 (1-10 μmol/kg) decreases immobility time in the FST to a level similar to that seen with 10-30 μmol/kg of the antidepressant Desipramine (HY-B1272A)[1].
JP1302 (5 μmol/kg, once) is capable of complete reversal of the impairment in PPI induced in Sprague-Dawley rats by the psychotomimetic NMDA receptor antagonist, phencyclidine and similar results are found in Wistar rats[1].
JP1302 (3 mg/kg, IV, once) significantly ameliorates renal dysfunction[3].

Animal Model:Male Sprague Dawley rats (8 weeks old)[3]
Dosage:3 mg/kg
Administration:IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion
Result:Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression.

IC 50

human α2C-adrenoceptor: 28±2 nM (Ki); human α2B-adrenoceptor: 1470±130 nM (Ki); human α2A-adrenoceptor: 3150±50 nM (Ki); rodent α2D-adrenoceptor: 1700±200 nM (Ki)

storage

Store at -20°C

JP 1302 2HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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JP 1302 2HCl Suppliers

China 41 United Kingdom 1 United States 7 USA 1 Global 50
Shanghai Lollane Biological Technology Co.,Ltd.
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View Lastest Price from JP 1302 2HCl manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
JP 1302 2HCl 1259314-65-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-09-18

1259314-65-2, JP 1302 2HClRelated Search:


  • JP 1302 2HCl
  • JP-1302 (hydrochloride)
  • JP-1302 HCl
  • N-(4-(4-Methylpiperazin-1-yl)phenyl)acridin-9-amine dihydrochloride
  • Inhibitor,JP 1302,JP-1302,JP1302 dihydrochloride,inhibit,JP1302,Beta Receptor,Adrenergic Receptor,JP-1302 dihydrochloride
  • JP1302 dihydrochloride, alpha2C antagonist
  • JP1302 dihydrochloride, 10 mM in DMSO
  • 1259314-65-2