6-chloro-4-(trifluoromethyl)nicotinonitrile

Product Name: 6-chloro-4-(trifluoromethyl)nicotinonitrile
CAS No.: 1201187-18-9
Chemical Name: 6-chloro-4-(trifluoromethyl)nicotinonitrile
Synonyms: 6-chloro-4-(trifluoromethyl)nicotinonitrile;6-Chloro-4-(trifluoromethyl)-3-pyridinecarbonitrile;6-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBONITRILE
CBNumber: CB03039537
Molecular Formula: C7H2ClF3N2
Formula Weight: 206.5523896
MOL File: 1201187-18-9.mol

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6-chloro-4-(trifluoromethyl)nicotinonitrile Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 8451DN
Product name: 6-Chloro-4-(trifluoromethyl)nicotinonitrile
Packaging: 100mg
Price: $116
Updated: 2021/12/16

Apolloscientific

Product number: PC201050
Product name: 6-Chloro-4-(trifluoromethyl)nicotinonitrile
Purity: 95%
Packaging: 250mg
Price: $300
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-7-0C
Product name: 6-Chloro-4-(trifluoromethyl)nicotinonitrile
Purity: 95%
Packaging: 250mg
Price: $480
Updated: 2021/12/16

Apolloscientific

Product number: PC201050
Product name: 6-Chloro-4-(trifluoromethyl)nicotinonitrile
Purity: 95%
Packaging: 1g
Price: $695
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-7-0C
Product name: 6-Chloro-4-(trifluoromethyl)nicotinonitrile
Purity: 95%
Packaging: 1g
Price: $1112
Updated: 2021/12/16

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6-chloro-4-(trifluoromethyl)nicotinonitrile Chemical Properties,Usage,Production

Synthesis

287922-66-1

896447-72-6

1201187-18-9

General procedure for the synthesis of 2-chloro-4-(trifluoromethyl)nicotinonitrile and 6-chloro-4-(trifluoromethyl)nicotinonitrile from 3-cyano-4-(trifluoromethyl)pyridine 1-oxide: 1. 3-cyano-4-(trifluoromethyl)pyridine 1-oxide (10.5 g, 55.8 mmol) was mixed with phosphorus trichloride (51 mL, 558 mmol) and the reaction was heated at 110 °C for 5 hours. 2. Upon completion of the reaction, excess phosphorous trichloride was removed by distillation under reduced pressure. 3. The residue was dissolved in dichloromethane and washed sequentially with 5% potassium carbonate solution and water. 4. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give a mixture of 2-chloro-4-(trifluoromethyl)nicotinonitrile and 6-chloro-4-(trifluoromethyl)nicotinonitrile. 5. The crude product was analyzed by 1H NMR, and the main product was determined to be 2-chloro-4-(trifluoromethyl)nicotinonitrile (ratio 7:3, 2-chloro:6-chloro). 6. The isomers were separated by fast column chromatography: the 6-chloro isomer was first eluted using a 9:1 hexane:triethylamine solvent mixture, followed by dichloromethane to obtain the target compound 2-chloro-4-(trifluoromethyl)nicotinonitrile as an orange oil (4.50 g, 38% yield).

References

[1] Patent: WO2006/68618, 2006, A1. Location in patent: Page/Page column 36-37

6-chloro-4-(trifluoromethyl)nicotinonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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6-chloro-4-(trifluoromethyl)nicotinonitrile Suppliers

China 37 India 1 United States 4 Global 42

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1201187-18-9, 6-chloro-4-(trifluoromethyl)nicotinonitrileRelated Search:

6-chloro-4-(trifluoromethyl)nicotinonitrile

6-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBONITRILE

6-Chloro-4-(trifluoromethyl)-3-pyridinecarbonitrile

1201187-18-9