CC-115
- Product Name
- CC-115
- CAS No.
- 1228013-15-7
- Chemical Name
- CC-115
- Synonyms
- CC-115;CS-2038;CC-115, >95%;CC115;CC 115;CC-115(free base);DNA-dependent protein kinase,inhibit,CC115,CC-115,DNA-PK,mTOR,Inhibitor,Mammalian target of Rapamycin;1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one;1-Ethyl-7-(2-methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one;Pyrazino[2,3-b]pyrazin-2(1H)-one, 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-
- CBNumber
- CB03041392
- Molecular Formula
- C16H16N8O
- Formula Weight
- 336.35
- MOL File
- 1228013-15-7.mol
CC-115 Property
- Boiling point:
- 587.3±60.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥50 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- form
- solid
- pka
- 5.94±0.20(Predicted)
- color
- Pink to red
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19420
- Product name
- CC-115
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19420
- Product name
- CC-115
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 19420
- Product name
- CC-115
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 19420
- Product name
- CC-115
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- CS-4561
- Product name
- CC-115
- Purity
- 96.64%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
CC-115 Chemical Properties,Usage,Production
Biological Activity
cc-115 is a inhibitor of mtor/dna-pk.the mammalian target of rapamycin (mtor) kinase is a key mediator of the phosphoinositide 3-kinase /protein kinase b (akt pathway). the dna-dependent protein kinase (dna-pk) is a critical component of the dna repair machinery governings the response to dna damage, which serves to maintain genome integrity.
in vitro
previous study found that the proliferation induced by cd40(+) interleukin-21 stimulation could be completely blocked by cc-115, and cd40-mediated resistance to fludarabine and venetoclax could also be reverted by cc-115. moreover, bcr-mediated signaling was blocked by cc-115 and in cll samples from patients with acquired resistance to idelalisib treatment [1].
in vivo
preclinical studies showed that cc-115 had good in vivo pk profiles across multiple species with 53%, 76%, and around100% oral bioavailability in mouse, rat, and dog, respectively [2].
target
| Target | Value |
| DNA-PK (Cell-free assay) | 0.013 μM |
| mTOR (Cell-free assay) | 0.021 μM |
| PI3Kα (Cell-free assay) | 0.852 μM |
IC 50
21/ 13 nm for mtor/dna-pk
References
[1] thijssen r,et al. dual tork/dna-pk inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. blood.2016 jul 28;128(4):574-83.
[2] mortensen ds, et al. optimization of a series of triazole containing mammalian target of rapamycin (mtor) kinase inhibitors and the discovery of cc-115. j med chem. 2015 jul 23;58(14):5599-5608.
CC-115 Preparation Products And Raw materials
Raw materials
Preparation Products
CC-115 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from CC-115 manufacturers
- Product
- CC-115 1228013-15-7
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05