Givinostat (hydrochloride)

Product Name: Givinostat (hydrochloride)
CAS No.: 199657-29-9
Chemical Name: Givinostat (hydrochloride)
Synonyms: ITF2357 HCl;Givinostat Hcl;ITF-2357 hydrochloride;Gavinostat hydrochloride;Givinostat (ITF2357) HCl;Givinostat (hydrochloride);Givinostat HCl. gavinostat;Givinostat (ITF2357) hydrochloride;GAVINOSTAT HYDROCHLORIDE;ITF-2357 HYDROCHLORIDE;inhibit,Givinostat hydrochloride,Histone deacetylases,Givinostat,Inhibitor,HDAC
CBNumber: CB03041408
Molecular Formula: C24H28ClN3O4
Formula Weight: 457.96
MOL File: 199657-29-9.mol

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Givinostat (hydrochloride) Property

storage temp.: Store at -20°C
solubility: DMSO:45.8(Max Conc. mg/mL);100.01(Max Conc. mM)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6249
Product name: Givinostathydrochloride
Purity: ≥98%(HPLC)
Packaging: 5
Price: $98
Updated: 2021/12/16

Tocris

Product number: 6249
Product name: Givinostathydrochloride
Purity: ≥98%(HPLC)
Packaging: 25
Price: $381
Updated: 2021/12/16

Crysdot

Product number: CD31002770
Product name: Givinostathydrochloride
Purity: 98+%
Packaging: 50mg
Price: $251
Updated: 2021/12/16

Crysdot

Product number: CD31002770
Product name: Givinostathydrochloride
Purity: 98+%
Packaging: 100mg
Price: $376
Updated: 2021/12/16

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Givinostat (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

Givinostat (ITF-2357) hydrochloride is an HDAC inhibitor, inhibits HDAC1 and HDAC3 with IC50 of 198 nM and 157 nM, respectively.

in vitro

Givinostat (hydrochloride) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduces IL-1β secretion more than 70%. Givinostat suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18.

in vivo

Givinostat (ITF2357) at 10 mg/kg is used as a positive control and reduces serum TNFα by 60%. Pretreatment of Givinostat (ITF-2357) starting at 0.1 mg/kg significantly reduces the circulating TNFα by nearly 90%. To achieve a significant increase in serum IL-1β production, a higher dose of LPS is injected (10 mg/kg), and blood is collected after 4 h.

target

hHDAC3

157 nM (IC ₅₀ )

hHDAC1

198 nM (IC ₅₀ )

hHDAC11

292 nM (IC ₅₀ )

hHDAC6

315 nM ( IC ₅₀ )

hHDAC2

325 nM (IC ₅₀ )

hHDAC10

340 nM (IC < sub> 50 )

hHDAC7

524 nM (IC ₅₀ )

hHDAC5

532 nM (IC ₅₀ )

hHDAC9

541 nM (IC ₅₀ )

hHDAC8

854 nM (IC _{50 < /sub> )}

hHDAC4

1059 nM (IC ₅₀ )

HD1-B

7.5 nM (IC ₅₀ )

HD1-A

16 nM (IC ₅₀ )

HD2

10 nM (IC ₅₀ )

storage

Store at -20°C

Givinostat (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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Givinostat (hydrochloride) Suppliers

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199657-29-9, Givinostat (hydrochloride)Related Search:

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inhibit,Givinostat hydrochloride,Histone deacetylases,Givinostat,Inhibitor,HDAC

199657-29-9